The 14q restless legs syndrome locus in the French Canadian population
The 14q restless legs syndrome locus in the French Canadian population
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DOI：
10.1002/ana.20140
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发表时间：
2004-06-01
影响因子：
11.2
通讯作者：
Rouleau, GA
中科院分区：
文献类型：
--
作者：
Levchenko, A;Montplaisir, JY;Rouleau, GA
最近在一个意大利家系中发现了一个位于14号染色体上的新的不宁腿综合征位点。我们的研究旨在复制这一发现，并确定该基因座在法裔加拿大人口的重要性。跨越该地区的标志物进行了基因分型，在14个大家庭和连锁使用两点和多点对数的赔率得分进行评估。在我们的一个kinestrian中发现了与该位点可能的连锁，这为该位点的存在提供了支持，并表明该位点可能与一小部分法裔加拿大人不宁腿综合征有关。
A new restless legs syndrome locus on chromosome 14 recently has been reported in one family of Italian origin. Our study aimed to replicate this finding and determine the importance of this locus in the French Canadian population. Markers spanning the region were genotyped in 14 large families and linkage assessed using two-point and multipoint logarithm of odds scores. Possible linkage to this locus was found in one of our kindreds providing support for the existence of this locus and indicating that this locus may be responsible for a small fraction of French Canadian restless legs syndrome.