Role of the parasympathetic system in antigen-induced bronchospasm.
Role of the parasympathetic system in antigen-induced bronchospasm.
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副交感系统在抗原诱导的支气管痉挛中的作用。
DOI：
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发表时间：
1977
期刊：
影响因子：
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通讯作者：
S. Permutt
中科院分区：
文献类型：
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作者：
Richard R. Rosenthal;Philip S. Norman;Warren R. Summer;S. Permutt
对豚草敏感的人类受试者在存在和不存在吸入性阿托品预处理的情况下吸入浓度不断增加的豚草花粉提取物的气溶胶。气道传导性降低35%所需的抗原累积剂量称为PD35。阿托品，1.2或5毫克，增加气道传导抗原挑战前，但没有改变显着的PD35豚草提取物，虽然这些剂量的阿托品抑制气道反应吸入乙酰甲胆碱氯化物和柠檬酸。我们的结论是胆碱能神经系统在支气管张力和刺激物的反应中起着调节作用，但副交感神经反射并不总是人支气管对吸入过敏原反应的主要组成部分。
Human subjects, sensitive to ragweed, inhaled aerosols of increasing concentrations of ragweed pollen extract in the presence and absence of pretreatment with inhaled atropine. The cumulative dose of antigen required for a 35% decrease in airways conductance was termed PD35. Atropine, 1.2 or 5 mg, increased airways conductance before antigenic challenge but did not alter signigicantly the PD35 for ragweed extract, although these doses of atropine inhibited airways responses to inhaled methacholine chloride and citric acid. We conclude that the cholinergic nervous system plays a modulating role in bronchomotor tone and responses to irritants, but that parasympathetic reflexes are not invariably a major component of human bronchial responses to inhaled allergen.