Larval midgut destruction in Drosophila: not dependent on caspases but suppressed by the loss of autophagy.
Larval midgut destruction in Drosophila: not dependent on caspases but suppressed by the loss of autophagy.
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DOI：
10.4161/auto.6.1.10601
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发表时间：
2010-01
期刊：
影响因子：
13.3
通讯作者：
Kumar S
中科院分区：
文献类型：
--
作者：
Denton D;Shravage B;Simin R;Baehrecke EH;Kumar S
虽然动物发育中的大多数程序性细胞死亡（PCD）依赖于 caspase 依赖性凋亡途径和随后的 caspase 底物裂解，但我们发现果蝇幼虫中肠中的 PCD 通常在缺乏凋亡机制的主要成分的情况下发生。然而，当自噬机制的某些组件被破坏时，中肠的破坏就会严重延迟。这些研究表明，果蝇中肠 PCD 是通过一种新机制执行的，其中 caspase 显然是可有可无的，但这需要自噬。
While most programmed cell death (PCD) in animal development is reliant upon the caspase-dependent apoptotic pathway and subsequent cleavage of caspase substrates, we found that PCD in Drosophila larval midgut occurs normally in the absence of the main components of the apoptotic machinery. However, when some of the components of the autophagic machinery were disrupted, midgut destruction was severely delayed. These studies demonstrate that Drosophila midgut PCD is executed by a novel mechanism where caspases are apparently dispensable, but that requires autophagy.