Computed tomography porosity and spherical indentation for determining cortical bone millimetre-scale mechanical properties
Computed tomography porosity and spherical indentation for determining cortical bone millimetre-scale mechanical properties
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DOI：
10.1038/s41598-019-43686-6
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发表时间：
2019-05-15
影响因子：
4.6
通讯作者：
Cobb, Justin P.
中科院分区：
文献类型：
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作者：
Boughton, Oliver R.;Ma, Shaocheng;Cobb, Justin P.
股骨颈皮质是人体的关键结构元素，但目前还没有可靠的指标来预测这一关键区域骨骼的机械性能。这项研究探索了使用一系列非破坏性指标来测量毫米长度尺度的股骨颈皮质骨刚度。评估了一系列测试方法和成像技术测量或预测从髋关节置换患者股骨颈获得的皮质骨样本的机械特性的能力。将可能应用于体内测量骨硬度的技术，包括计算机断层扫描 (CT)、体波超声 (BWUS) 和压痕，与体外技术（包括压缩测试、密度测量和共振超声光谱）进行比较。通过显微 CT 测量的孔隙率与股骨颈皮质骨的弹性模量和毫米长度尺度的极限抗压强度相关。大尖端球形压痕也与该长度尺度的骨机械特性相关，但程度较小。由于皮质骨的弹性机械特性与孔隙率相关，我们建议进一步开发能够安全测量体内皮质孔隙率的技术。
The cortex of the femoral neck is a key structural element of the human body, yet there is not a reliable metric for predicting the mechanical properties of the bone in this critical region. This study explored the use of a range of non-destructive metrics to measure femoral neck cortical bone stiffness at the millimetre length scale. A range of testing methods and imaging techniques were assessed for their ability to measure or predict the mechanical properties of cortical bone samples obtained from the femoral neck of hip replacement patients. Techniques that can potentially be applied in vivo to measure bone stiffness, including computed tomography (CT), bulk wave ultrasound (BWUS) and indentation, were compared against in vitro techniques, including compression testing, density measurements and resonant ultrasound spectroscopy. Porosity, as measured by micro-CT, correlated with femoral neck cortical bone's elastic modulus and ultimate compressive strength at the millimetre length scale. Large-tip spherical indentation also correlated with bone mechanical properties at this length scale but to a lesser extent. As the elastic mechanical properties of cortical bone correlated with porosity, we would recommend further development of technologies that can safely measure cortical porosity in vivo.