Hepatitis A among homosexual men and injection drug users: more evidence for vaccination.
Hepatitis A among homosexual men and injection drug users: more evidence for vaccination.
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同性恋男性和注射吸毒者中的甲型肝炎：疫苗接种的更多证据。
DOI：
10.1086/513757
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Thomas,DL
中科院分区：
文献类型：
--
作者：
Villano,SA;Nelson,KE;Vlahov,D;Purcell,RH;Saah,AJ;Thomas,DL
随着各机构制定新开发的甲型肝炎病毒（HAV）疫苗的管理指南，需要有关感染高危人群中HAV感染发生情况的信息。我们检测了300名注射吸毒者（IDUs）、300名同性恋男性和300名献血员的血清样本，以确定是否存在甲型肝炎病毒（HAV）总抗体。在66%的注射吸毒者、32%的同性恋男性和14%的献血者中检测到抗HAV。抗-HAV与高危吸毒行为无显著相关性（P> 0.10），但在年收入<5，000美元的注射吸毒者中更为普遍（P= 0.018）。随着性伴侣数量的增加，男性同性恋者中抗HAV的发生率增加（P<0.001），但与美国一般人群估计的年龄调整患病率（30.6%）相似。注射吸毒者感染甲型肝炎病毒的风险增加，然而，我们的数据表明，与低社会经济地位有关的因素比注射吸毒者更容易感染甲型肝炎病毒。注射吸毒者和有注射吸毒危险的人应接种甲型肝炎疫苗。
As agencies develop guidelines for administering the newly developed hepatitis A virus (HAV) vaccine, information is needed regarding the occurrence of HAV infection in groups putatively at risk for the infection. We tested serum samples from 300 injection drug users (IDUs), 300 homosexual males, and 300 blood donors for the presence of total antibody to HAV (anti-HAV). Anti-HAV was detected in 66% of IDUs, 32% of homosexual males, and 14% of blood donors. Anti-HAV was not significantly associated (P> .10) with high-risk drug-using behaviors but was more prevalent among IDUs with annual incomes of <$5,000 (P= .018). The occurrence of anti-HAV increased among homosexual males as the number of sexual partners increased (P< .001) but was similar to the age-adjusted prevalence (30.6%) estimated for the general United States population. IDUs are at increased risk for HAV infection; however, our data suggest that factors related to low socioeconomic status contribute more to the occurrence of HAV infection among IDUs than does injection drug use. IDUs and persons at risk for injection drug use should receive HAV vaccine.