The effect of metabolic syndrome defined by various criteria on the development of ischemic stroke subtypes in a general Japanese population
The effect of metabolic syndrome defined by various criteria on the development of ischemic stroke subtypes in a general Japanese population
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DOI：
10.1016/j.atherosclerosis.2009.10.044
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发表时间：
2010-05-01
期刊：
影响因子：
5.3
通讯作者：
Kiyohara, Yutaka
中科院分区：
文献类型：
--
作者：
Hata, Jun;Doi, Yasufumi;Kiyohara, Yutaka
目的：我们评估的影响，代谢综合征（MetS）定义的各种标准对缺血性中风亚型的发生在一般Japanese population.Methods：一个日本社区，久山，年龄40岁或以上，共2452名居民，随访14年。敬德。在MetS中，我们使用了原始日本标准、修改的日本标准、国际糖尿病联合会（IDF）标准、原始国家胆固醇教育计划成人治疗组III（NCEP）标准和修改的NCEP标准。我们用男性腰围>= 90 cm和女性腰围>= 80 cm分别代替日本标准中的腰围>= 85 cm和腰围>= 90 cm，用NCEP标准中的腰围>102 cm和腰围>= 88 cm。只有改良日本标准定义的代谢综合征与腔隙性脑梗死的发生有显著相关性，其发生动脉粥样硬化血栓性和心源性梗死的危险比（HR）显著大于其他标准定义的MetS：腔隙性、动脉粥样硬化血栓性和心源性梗死的校正HR为1.94（95%置信区间（CI），1.13-3.32; P = 0.02），2.55（95% CI，1.25-5.18; P = 0.01）和3.94（95%CI，1.89-8.22，P < 0.001）。结论：我们的研究结果表明，MetS定义的日本标准与modi。在日本人群中，男性腰围≥ 90 cm和女性腰围≥ 80 cm是每种缺血性卒中亚型的较好预测因子。(C)2009爱思唯尔爱尔兰有限公司保留所有权利。
Objective: We evaluated the impact of metabolic syndrome (MetS) defined by various criteria on the occurrence of ischemic stroke subtypes in a general Japanese population.Methods: A total of 2452 residents of a Japanese community, Hisayama, aged 40 years or older, were followed up for 14 years. To de. ne MetS, we used the original Japanese criteria, the modified Japanese criteria, the International Diabetes Federation (IDF) criteria, the original National Cholesterol Education Program's Adult Treatment Panel III (NCEP) criteria, and the modified NCEP criteria. We substituted a waist circumference of >= 90 cm in men and >= 80 cm in women for the values of >= 85 cm and >= 90 cm, respectively, in the modified Japanese criteria and for >102 cm and >88 cm, respectively, in the modified NCEP criteria.Results: Only MetS defined by the modified Japanese criteria showed a significant association with the development of lacunar infarction, and its hazard ratios (HRs) for the development of atherothrombotic and cardioembolic infarction were significant and greater than those of MetS defined by the other criteria: adjusted HRs for lacunar, atherothrombotic and cardioembolic infarction were 1.94 (95% confidence interval (CI), 1.13-3.32; P = 0.02), 2.55 (95% CI, 1.25-5.18; P = 0.01) and 3.94 (95% CI, 1.89-8.22, P < 0.001), respectively, after adjustment for confounding factors.Conclusion: Our findings suggest that MetS defined by the Japanese criteria with the modi. cation of a waist circumference of >= 90 cm in men and >= 80 cm in women is a better predictor of each ischemic stroke subtype in the Japanese population. (C) 2009 Elsevier Ireland Ltd. All rights reserved.