Serum 25-Hydroxyvitamin D Levels and Rate of Hip Bone Loss in Older Men
Serum 25-Hydroxyvitamin D Levels and Rate of Hip Bone Loss in Older Men
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DOI：
10.1210/jc.2008-2786
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发表时间：
2009-08-01
影响因子：
5.8
通讯作者：
Orwoll, Eric S.
中科院分区：
文献类型：
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作者：
Ensrud, Kristine E.;Taylor, Brent C.;Orwoll, Eric S.
内容：维生素D缺乏症在老年人中很常见，但25-羟基维生素D [25（OH）D]水平与骨质流失率之间的关系尚不确定。S. centers.Participants:共有1279名年龄在65岁或以上的社区居住男性25（OH）D水平（液相色谱-串联质谱法）和髋骨矿物质密度（BMD）（双能X线骨密度仪）在基线和重复髋关节BMD平均4.4年后参加了这项研究。主要结果测量：我们测量了髋关节BMD的年变化率。校正多个潜在混杂因素后，25（OH）D水平低于15.0 ng/ml的男性的全髋BMD平均下降率为-0.59%/年，25（OH）D水平15.0-19.9 ng/ml的男性为-0.54%/年，25（OH）D水平20.0-29.9 ng/ml的男性为-0.35%/年，25（OH）D水平至少为30 ng/ml的男性为-0.37%/年（多变量模型的P趋势= 0.008）。证据有力地支持75岁及以上男性之间的关联（P趋势
Context: Vitamin D deficiency is common among older adults, but the association between 25-hydroxyvitamin D [25(OH) D] levels and rates of bone loss is uncertain.Objective: Our aim was to test the hypothesis that lower 25(OH) D levels are associated with higher rates of hip bone loss in older men.Design and Setting: We conducted a prospective cohort study in six U. S. centers.Participants: A total of 1279 community-dwelling men aged 65 yr or older with 25(OH) D levels (liquid chromatography-tandem mass spectroscopy) and hip bone mineral density (BMD) (dual-energy x-ray absorptiometry) at baseline and repeat hip BMD an average of 4.4 yr later participated in the study.Main Outcome Measure(s): We measured the annualized percentage rate of change in hip BMD.Results: After adjustment for multiple potential confounders, the average rate of decline in total hip BMD was -0.59%/yr among men with 25(OH) D levels below 15.0 ng/ml, -0.54%/yr among men with 25(OH) D levels 15.0-19.9 ng/ml, -0.35%/yr among men with 25(OH) D levels 20.0-29.9 ng/ml, and -0.37%/ yr among men with 25(OH) D levels of at least 30 ng/ml (P trend = 0.008 for multivariable model). Evidence was strong to support an association among men aged 75 yr and older (P trend