ASSOCIATION BETWEEN AUTOIMMUNE THYROID-DISEASE AND FAMILIAL ALZHEIMERS-DISEASE
ASSOCIATION BETWEEN AUTOIMMUNE THYROID-DISEASE AND FAMILIAL ALZHEIMERS-DISEASE
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DOI：
10.1111/j.1365-2265.1991.tb03502.x
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发表时间：
1991-07-01
影响因子：
3.2
通讯作者：
MCGREGOR, AM
中科院分区：
文献类型：
--
作者：
EWINS, DL;ROSSOR, MN;MCGREGOR, AM
目的了解家族性阿尔茨海默病家族中自身免疫性甲状腺疾病的患病率，并确定这两种疾病之间是否存在遗传联系的证据。家族性阿尔茨海默病的回顾性研究。病人：来自12个种族的70名受影响和未受影响的家庭成员。测定方法：采用酶联免疫吸附法测定抗甲状腺球蛋白和抗微粒体自身抗体状态。用免疫放射测定法测定促甲状腺素水平。结果41.4%的家庭成员存在自身免疫性甲状腺疾病，甲状腺自身抗体的存在与阿尔茨海默病的发展之间存在显著的共分离（P < 0.01）。结论：本研究表明家族性阿尔茨海默病家族中自身免疫性甲状腺疾病的患病率非常高，并提示一个促进自身免疫性甲状腺疾病发展的遗传因素可能位于21号染色体上，靠近家族性阿尔茨海默病基因。
OBJECTIVE To determine the prevalence of autoimmune thyroid disease in Familial Alzheimer's Disease kindreds and to ascertain whether there is any evidence for genetic linkage between the two conditions.DESIGN Retrospective study of Familial Alzheimer's Disease kindreds.PATIENTS Seventy affected and unaffected family members from 12 kindreds.MEASUREMENTS Anti-thyroglobulin and anti-microsomal autoantibody status was determined using an enzyme-linked immunosorbent assay. Thyrotrophin levels were determined by an immunoradiometric assay.RESULTS Of the family members, 41.4% had evidence of autoimmune thyroid disease, with significant co-segregation between the presence of thyroid autoantibodies and the development of Alzheimer's disease (P < 0.01).CONCLUSIONS This study demonstrates a very high prevalence of autoimmune thyroid disease in Familial Alzheimer's Disease kindreds and suggests that a genetic factor contributing towards the development of autoimmune thyroid disease may be located on chromosome 21 within close proximity to the Familial Alzheimer's Disease gene.