Mortality from cirrhosis and hepatocellular carcinoma in Western Europe over the last 40 years
Mortality from cirrhosis and hepatocellular carcinoma in Western Europe over the last 40 years
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DOI：
10.1111/liv.13371
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发表时间：
2017-08-01
影响因子：
6.7
通讯作者：
De Luca, Massimo
中科院分区：
文献类型：
--
作者：
Ascione, Antonio;Fontanella, Luca;De Luca, Massimo
背景和目标：肝硬化（LC）和肝细胞癌（HCC）在欧洲非常普遍，伴随着高死亡率和社会成本。由于这些疾病的流行病学数据是稀缺的，年龄标准化死亡率（ASDR）可以作为一个间接的评估他们的burden. Methods：我们分析了ASDR LC和HCC从WHO官方死亡登记处报告的数据，从1970年至2010年，并比较ASDR的几十年。欧洲详细的死亡率数据库也被用作data.Results的来源：在1970年，葡萄牙报告的LC死亡率最高，其次是法国和意大利。然而，在2010年，芬兰、奥地利和德国分别是最高的三个国家，而英国在这四十年中的增幅最高（+284.8%）。在欧洲，LC的年度ASDR从1970年的20.4/10（5）居民下降到2010年的9.6;下降了53%。对于HCC，西班牙，意大利和丹麦排名第一至第三，而在2010年，意大利，法国和卢森堡取代了他们。葡萄牙的增幅最高（+654.7%）。1980 - 2010年，欧洲HCC的ASDR从3.4/10（5）居民增加到6.3，增长了85.4%。在大多数国家，除了英国，芬兰和爱尔兰，有一个降低LC死亡率和增加HCC mortality. Conclusions：LC死亡率在欧洲下降，但有一个显着增加HCC死亡率。这种现象需要更多的关注，以便我们能够了解风险因素并采取预防措施。
Background & Aims: Cirrhosis (LC) and hepatocellular carcinoma (HCC) are highly prevalent in Europe, with accompanying high mortality rates and social costs. As epidemiological data on these diseases are scarce, age-standardized death rate (ASDR) can serve as an indirect assessment of their burden.Methods: We analysed the ASDRs for LC and HCC from data reported in the WHO official death registries from 1970 to 2010, and compared ASDRs over the decades. The European Detailed Mortality Database was also used as source of data.Results: In 1970, Portugal had the highest reported mortality for LC, followed by France and Italy. However, in 2010, Finland, Austria and Germany were respectively the three highest, while the UK showed the highest increase over those four decades (+284.8%). The annual ASDRs for LC have dropped in Europe from 20.4/10(5) inhabitants in 1970 to 9.6 in 2010; a 53% decrease. For HCC, Spain, Italy and Denmark were ranked first through third, while in 2010 Italy, France and Luxembourg replaced them. Portugal had the highest increase (+654.7%). In 1980-2010, the ASDR for HCC in Europe increased from 3.4/10(5) inhabitants to 6.3, up 85.4%. In the majority of nations-except for the UK, Finland and Ireland-there was a decrease in LC mortality and an increase for HCC mortality.Conclusions: The LC mortality rate is decreasing in Europe, yet there is a significant increase in HCC mortality. This phenomenon requires greater attention so we can understand the risk factors and implement preventive measures.