Distinct roles for visceral endoderm during embryonic mouse development.
Distinct roles for visceral endoderm during embryonic mouse development.
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DOI：
10.1387/ijdb.10410899
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发表时间：
1999
期刊：
影响因子：
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通讯作者：
M. Bielińska;N. Narita;D. B. Wilson
中科院分区：
文献类型：
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作者：
M. Bielińska;N. Narita;D. B. Wilson
小鼠内脏内胚层是胚胎外细胞层，在原肠胚形成之前出现，在胚胎发生过程中起关键作用。传统认为内脏内胚层的作用是吸收和运输营养物质。胚胎外内脏内胚层除了合成一些促进营养物质摄取、消化和分泌的特殊蛋白质外，还协调相邻中胚层的血细胞分化和血管形成，从而促进母体和胚胎之间营养物质和气体的有效交换。最近的研究表明，除了这种营养交换功能外，卵筒期胚胎上覆盖的内脏内胚层在指导早期发育中起着积极的作用。前内脏内胚层细胞起早期组织者的作用。在原始条纹形成之前，这些细胞表达特定的基因产物，指定潜在胚胎组织的命运。在这篇综述中，我们强调了最近的研究表明内脏内胚层作为早期胚胎的营养和发育线索的提供者的双重作用。
The murine visceral endoderm is an extraembryonic cell layer that appears prior to gastrulation and performs critical functions during embryogenesis. The traditional role ascribed to the visceral endoderm entails nutrient uptake and transport. Besides synthesizing a number of specialized proteins that facilitate uptake, digestion, and secretion of nutrients, the extraembryonic visceral endoderm coordinates blood cell differentiation and vessel formation in the adjoining mesoderm, thereby facilitating efficient exchange of nutrients and gases between the mother and embryo. Recent studies suggest that in addition to this nutrient exchange function the visceral endoderm overlying the egg cylinder stage embryo plays an active role in guiding early development. Cells in the anterior visceral endoderm function as an early organizer. Prior to formation of the primitive streak, these cells express specific gene products that specify the fate of underlying embryonic tissues. In this review we highlight recent investigations demonstrating this dual role for visceral endoderm as a provider of both nutrients and developmental cues for the early embryo.