Erythrocyte and brain forms of spectrin in cerebellum: distinct membrane-cytoskeletal domains in neurons.
Erythrocyte and brain forms of spectrin in cerebellum: distinct membrane-cytoskeletal domains in neurons.
复制标题
小脑中血影蛋白的红细胞和大脑形式：神经元中不同的膜细胞骨架结构域。
作者：
E. Lazarides;W. Nelson
鸡小脑表达一种与血影蛋白α亚基（一种红细胞膜细胞骨架蛋白）抗原性和生物化学相关的多肽。这种多肽的大部分与脑特异性血影蛋白亚基γ-血影蛋白相关，并且定位于几乎所有神经元细胞体和过程中。小脑还表达与红细胞血影蛋白的β亚基抗原相关的多肽，并且这些多肽也被发现与小脑α-血影蛋白相关，但仅限于神经元细胞体的质膜。这表明，在单个细胞内存在将不同血影蛋白复合物分离成不同膜结构域的机制。
Chicken cerebellum expresses a polypeptide antigenically and biochemically related to the alpha subunit of spectrin, an erythrocyte membrane-cytoskeletal protein. Most of this polypeptide is associated with a brain specific spectrin subunit, gamma-spectrin, and is localized in virtually all neuronal cell bodies and processes. Cerebellum also expresses polypeptides antigenically related to the beta subunits of erythrocyte spectrin and these are also found in association with cerebellar alpha-spectrin but are confined to the plasmalemma of the neuronal cell bodies. This suggests that there is a mechanism for segregating different spectrin complexes into distinct membrane domains within a single cell.
一种主要的钙调蛋白结合蛋白，常见于各种脊椎动物组织。
DOI：
10.1073/pnas.79.12.3780
发表时间：
1982
影响因子：
11.1
作者：
Palfrey,HC;Schiebler,W;Greengard,P
通讯作者：
Greengard,P