Toll-like receptor 4 surface expression on human monocytes and B cells is modulated by IL-2 and IL-4
Toll-like receptor 4 surface expression on human monocytes and B cells is modulated by IL-2 and IL-4
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DOI：
10.1016/s0165-2478(01)00328-5
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发表时间：
2002-04-01
影响因子：
4.4
通讯作者：
Mori, M
中科院分区：
文献类型：
--
作者：
Mita, Y;Dobashi, K;Mori, M
人Toll样受体4（TLR 4）最近被鉴定。并且它被认为是参与识别革兰氏阴性细菌的主要蛋白质。我们研究了白细胞介素2（IL-2）和IL-4对人外周血单核细胞和B细胞中TLR 4表面表达的调节。IL-2上调人外周血单核细胞表面TLR 4的表达但不改变人外周B细胞上的表达。相比之下，IL-4不调节人外周血单核细胞表面TLR 4的表达。但上调人外周B细胞表面TLR 4的表达。这些结果表明，Th 1细胞因子IL-2增强参与革兰氏阴性菌的应答的受体，并且细胞免疫的激活可能通过单核细胞而不是B细胞增强对这些病原体的防御，而Th-2细胞因子IL-4调节对革兰氏阴性菌的受体应答，并且体液免疫的激活可能通过B细胞而不是单核细胞增强对这些病原体的防御。(C)2002 Elsevier Science B. V.保留所有权利。
Human Toll-like receptor 4 (TLR4) has recently been identified. and it has been shogun to be the main protein involved in recognizing gram-negative bacteria. We examined the regulation of TLR4 surface expression in human peripheral blood monocytes and B cells by interleukin-2 (IL-2) and IL-4. IL-2 up-regulated TLR4 surface expression on human peripheral blood monocytes. but did not change expression on human peripheral B cells. By contrast, IL-4 don-regulated TLR4 surface expression on human peripheral blood monocytes. but up-regulated TLR4 surface expression on human peripheral B cells. These results indicate that Th1 cytokine IL-2 enhances receptors involved in the response to gram-negative bacteria and that activation of cellular immunity may enhance defense against these pathogens through monocytes, but not B cells, whereas Th-2 cytokine IL-4 modulates the receptor response to gram-negative bacteria and that activation of humoral immunity may enhance defense against these pathogens through B cells, but not monocytes. (C) 2002 Elsevier Science B.V. All rights reserved.