3,4,3',4'-TETRACHLOROBIPHENYL GIVEN TO MICE PRENATALLY PRODUCES LONG-TERM DECREASES IN STRIATAL DOPAMINE AND RECEPTOR-BINDING SITES IN THE CAUDATE-NUCLEUS
3,4,3',4'-TETRACHLOROBIPHENYL GIVEN TO MICE PRENATALLY PRODUCES LONG-TERM DECREASES IN STRIATAL DOPAMINE AND RECEPTOR-BINDING SITES IN THE CAUDATE-NUCLEUS
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DOI：
10.1016/0378-4274(81)90087-4
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发表时间：
1981-01-01
影响因子：
3.5
通讯作者：
BONDY, SC
中科院分区：
文献类型：
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作者：
AGRAWAL, AK;TILSON, HA;BONDY, SC
妊娠CD-1小鼠在妊娠第10-16天通过管饲法给予32 mg/kg的3，4，3“，4”-四氯联苯（TCB）或玉米油溶剂。在1年，后代进行了测试，自发运动活动，然后杀死多巴胺（DA）水平和特定的DA受体结合纹状体进行了测量。在子宫内暴露于TCB的小鼠具有升高的运动活动水平，这与降低的DA水平和DA受体结合位点相关。在子宫内暴露于TCB可能会永久改变纹状体突触的发育。
Pregnant CD-1 mice were given 32 mg/kg of 3,4,3'',4''-tetrachlorobiphenyl (TCB) or corn oil vehicle by gavage on days 10-16 of gestation. At 1 yr, offspring were tested for spontaneous motor activity and then killed; dopamine (DA) levels and specific DA receptor binding were measured in corpus striatum. Mice exposed to TCB in utero had elevated levels of motor activity which were associated with decreased DA levels and DA receptor binding sites. In utero exposure to TCB might permanently alter development of striatal synapses.