Integrating quantitative morphological and intratumoural textural characteristics in FDG-PET for the prediction of prognosis in pharynx squamous cell carcinoma patients
Integrating quantitative morphological and intratumoural textural characteristics in FDG-PET for the prediction of prognosis in pharynx squamous cell carcinoma patients
复制标题
DOI：
10.1016/j.crad.2018.08.011
复制
发表时间：
2018-12-01
影响因子：
2.6
通讯作者：
Shirato, H.
中科院分区：
文献类型：
--
作者：
Fujima, N.;Hirata, K.;Shirato, H.
目的：通过2-[F-18]-氟-2-脱氧-N-葡萄糖正电子发射计算机断层扫描(FDG-PET/CT)获得的定量形态和瘤内特征，评价咽鳞癌患者的潜在预后因素。材料和方法：对54例接受放化疗的咽鳞癌患者进行回顾性分析。使用他们的FDG-PET数据，计算了14个参数的定量形态特征和瘤内特征。无进展生存期(PFS)和总生存期(OS)信息来源于患者病历。进行单变量和多变量分析，以评估14个定量参数以及T分期、N分期和肿瘤位置数据与PFS和OS的关系。结果：在PFS的评价中，单变量和多变量分析表明：质地参数的均质性和球形性的形态参数是独立预测因素。在Kaplan-Meier分析中，均质度(p=0.01)和球形度(p=0.002)值高的患者的PFS率显著提高。结论：FDG-PET获得的均质性和球形性定量参数可用于预测咽部鳞状细胞癌患者的PFS，尤其是联合使用时。(C)2018年皇家放射科医生学会。爱思唯尔有限公司出版。保留所有权利。
AIM: To assess potential prognostic factors in pharynx squamous cell carcinoma (SCC) patients by quantitative morphological and intratumoural characteristics obtained by 2-[F-18]-fluoro-2-deoxy-n-glucose positron-emission tomography/computed tomography (FDG-PET/ CT).MATERIALS AND METHODS: The cases of 54 patients with pharynx SCC who underwent chemoradiation therapy were analysed retrospectively. Using their FDG-PET data, the quantitative morphological and intratumoural characteristics of 14 parameters were calculated. The progression-free survival (PFS) and overall survival (OS) information was obtained from patient medical records. Univariate and multivariate analyses were performed to assess the 14 quantitative parameters as well as the T-stage, N-stage, and tumour location data for their relation to PFS and OS. When an independent predictor was suggested in the multivariate analysis, the parameter was further assessed using the Kaplan-Meier method.RESULTS: In the assessment of PFS, the univariate and multivariate analyses indicated the following as independent predictors: the texture parameter of homogeneity and the morphological parameter of sphericity. In the Kaplan-Meier analysis, the PFS rate was significantly improved in the patients who had both a higher value of homogeneity (p=0.01) and a higher value of sphericity (p=0.002). With the combined use of homogeneity and sphericity, the patients with different PFS rates could be divided more clearly.CONCLUSION: The quantitative parameters of homogeneity and sphericity obtained by FDG-PET can be useful for the prediction of the PFS of pharynx SCC patients, especially when used in combination. (C) 2018 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.