ABNORMAL MEMBRANE GLYCOPROTEIN ASSOCIATED WITH MALIGNANCY IN A WIDE-RANGE OF DIFFERENT TUMORS
ABNORMAL MEMBRANE GLYCOPROTEIN ASSOCIATED WITH MALIGNANCY IN A WIDE-RANGE OF DIFFERENT TUMORS
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DOI：
10.1098/rspb.1978.0034
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发表时间：
1978-01-01
期刊：
影响因子：
--
通讯作者：
HARRIS, H
中科院分区：
文献类型：
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作者：
BRAMWELL, ME;HARRIS, H
通过细胞在体内进行性生长的能力来测量的细胞增殖与1种特定膜糖蛋白的多糖部分中的结构异常的存在密切相关。这种异常存在于广泛的人类和小鼠肿瘤中。它与恶性肿瘤共分离，在所有的恶性和非恶性细胞之间的交叉，迄今已被测试。在一项严格的新试验中，它仍然与恶性肿瘤有关，在该试验中，通过使用凝集素从肿瘤细胞群中选择非恶性变体。
Malignancy, as measured by the ability of cells to grow progressively in vivo, is intimately linked to the presence of a structural abnormality in the polysaccharide moiety of 1 particular membrane glycoprotein. This abnormality is present in a wide range of human and mouse tumors. It cosegregates with malignancy in all crosses between malignant and nonmalignant cells that have so far been tested. It remains linked to malignancy in a stringent new test in which nonmalignant variants are selected from tumor cell populations by use of a lectin.