MECHANISM OF ACTION OF NARCOTIC ANALGESICS IN GUINEA-PIG ILEUM
MECHANISM OF ACTION OF NARCOTIC ANALGESICS IN GUINEA-PIG ILEUM
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DOI：
10.1111/j.1476-5381.1977.tb07546.x
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发表时间：
1977-01-01
影响因子：
7.3
通讯作者：
TONINI, M
中科院分区：
文献类型：
--
作者：
NORTH, RA;TONINI, M
1.从豚鼠回肠肌间神经丛中的神经元进行细胞内记录。在体外维持单个肌间神经节，并通过将其加入灌注液中来施加药物。2.麻醉性镇痛药使肌间神经丛中一部分神经元的膜超极化。3.膜超极化有时与输入电阻的降低有关。这些作用降低了肌间神经元的兴奋性。4.麻醉剂的作用发生在低浓度（10 nM至1 μ m），是立体特异性的，并被纳洛酮逆转。5.提示吗啡敏感神经元可能是肌层的胆碱能传出神经。通过使这些神经元超极化，吗啡可以防止它们被电场刺激兴奋。这可以解释为什么麻醉性镇痛药减少乙酰胆碱的输出和这种制剂在被场刺激兴奋时的收缩反应。
1. Intracellular recordings were made from neurones in the myenteric plexus of the guinea-pig ileum. Single myenteric ganglia were maintained in vitro and drugs were applied by adding them to the perfusing solution. 2. Narcotic analgesics hyperpolarized the membrane of a proportion of neurones in the myenteric plexus. 3. The membrane hyperpolarization was sometimes associated with a decrease in input resistance. These effects reduced the excitability of myenteric neurones. 4. The effects of narcotics occurred at low concentrations (10 nM to 1 micrometer), were stereospecific and were reversed by naloxone. 5. It is proposed that the morphine-sensitive neurones may be the cholinergic efferents to the muscle layers. By hyperpolarizing these neurones, morphine may prevent their excitation by electric field stimulation. This may explain why narcotic analgesics reduce the output of acetylcholine and the contractile response of this preparation when it is excited by field stimulation.