Prevalence of narcolepsy symptomatology and diagnosis in the European general population
Prevalence of narcolepsy symptomatology and diagnosis in the European general population
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DOI：
10.1212/wnl.58.12.1826
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发表时间：
2002-06-25
期刊：
影响因子：
9.9
通讯作者：
Paiva, T
中科院分区：
文献类型：
--
作者：
Ohayon, MM;Priest, RG;Paiva, T
目的：确定五个欧洲国家一般人群（目标人群205，890，882名居民）中发作性睡病的患病率。方法：总体而言，18，980名随机选择的受试者接受了采访（参与率为80.4%）。这些受试者代表了英国德国、意大利、葡萄牙和西班牙的一般人群。他们通过使用Sleep-EVAL专家系统进行电话采访，该系统根据国际睡眠障碍分类（ICSD）提供嗜睡症诊断。结果：15%的样本报告了白天过度嗜睡，在英国和德国的患病率更高。在同一天小睡两次或两次以上的比例为1.6%，德国的比例明显更高。发作性睡病的一个主要症状，即痉挛（与强烈情绪有关的肌肉功能丧失），在1.6%的样本中被发现。在0.047%的样本中发现ICSD嗜睡症诊断：0.026%的样本中嗜睡症为重度，0.021%为中度。结论：这是第一项估计这五个欧洲国家一般人群中发作性睡病患病率的流行病学研究。每100 000名居民中有47人患有这种疾病。
Objective: To determine the prevalence of narcolepsy in the general population of five European countries (target population 205,890,882 inhabitants). Methods: Overall, 18,980 randomly selected subjects were interviewed (participation rate 80.4%). These subjects were representative of the general population of the UK Germany, Italy, Portugal, and Spain. They were interviewed by telephone using the Sleep-EVAL expert system, which provided narcolepsy diagnosis according to the International Classification of Sleep Disorders (ICSD). Results: Excessive daytime sleepiness was reported by 15% of the sample, with a higher prevalence in the UK and Germany. Napping two times or more in the same day was reported by 1.6% of the sample, with a significantly higher rate in Germany. Cataplexy (episodes of loss of muscle function related to a strong emotion), a cardinal symptom of narcolepsy, was found in 1.6% of the sample. An ICSD narcolepsy diagnosis was found in 0.047% of the sample: The narcolepsy was severe for 0.026% of the sample and moderate in 0.021%. Conclusion: This is the first epidemiologic study that estimates the prevalence of narcolepsy in the general population of these five European countries. The disorder affects 47 individuals/100,000 inhabitants.