Microfluidics of nano-drug delivery
Microfluidics of nano-drug delivery
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DOI：
10.1016/j.ijheatmasstransfer.2008.04.043
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发表时间：
2008-11-01
影响因子：
5.2
通讯作者：
Koo, Junemo
中科院分区：
文献类型：
--
作者：
Kleinstreuer, Clement;Li, Jie;Koo, Junemo
在简要回顾了微流体技术之后，介绍了微通道中纳米流体流动的生物MEMS应用。具体而言，瞬态3-D问题的控制纳米药物输送在加热的微通道已被数值解决，以获得新的物理见解，并确定合适的几何和操作系统参数。通过数值试验和与基准实验数据集的比较，验证了计算机模型的准确性。通过考虑不同的微通道长度、纳米颗粒直径、通道流速、壁热通量面积和纳米流体供应速率的计算机实验，实现了微通道出口平面处的纳米药物浓度接近均匀和期望的混合物流体温度的总体设计目标。在实验室测试植入式智能设备的前身以及分析药物和执行生物医学精密任务中非常重要。(C)2008爱思唯尔有限公司保留所有权利。
After a brief review of microfluidics, a bio-MEMS application in terms of nanofluid flow in microchannels is presented. Specifically, the transient 3-D problem of controlled nano-drug delivery in a heated microchannel has been numerically solved to gain new physical insight and to determine suitable geometric and operational system parameters. Computer model accuracy was verified via numerical tests and comparisons with benchmark experimental data sets. The overall design goals of near-uniform nano-drug concentration at the microchannel exit plane and desired mixture fluid temperature were achieved with computer experiments considering different microchannel lengths, nanoparticle diameters, channel flow rates, wall heat flux areas, and nanofluid supply rates.Such micro-systems, featuring controlled transport processes for optimal nano-drug delivery, are important in laboratory-testing of predecessors of implantable smart devices as well as for analyzing pharmaceuticals and performing biomedical precision tasks. (C) 2008 Elsevier Ltd. All rights reserved.