Relation between methamphetamine-induced monoamine depletions in the striatum and sequential motor learning
Relation between methamphetamine-induced monoamine depletions in the striatum and sequential motor learning
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DOI：
10.1016/j.pbb.2005.03.010
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发表时间：
2005-05-01
影响因子：
3.6
通讯作者：
Keefe, KA
中科院分区：
文献类型：
--
作者：
Daberkow, DP;Kesner, RP;Keefe, KA
甲基苯丙胺（METH）的使用导致纹状体中单胺的消耗。本研究的目的是评估在大鼠纹状体中的甲硫氨酸诱导的单胺耗竭的程度和纹状体依赖性学习任务的损害之间的关系。雄性Sprague-Dawley大鼠以2小时间隔接受四次METH（10 mg/kg）或盐水注射。METH处理在内侧和外侧纹状体中分别产生38.5%（+/-5.6）和46.7%（+/-6.7）的多巴胺（DA）消耗。在内侧和外侧纹状体中，5-羟色胺（5-HT）分别消耗15.6%（+/- 10.4）和21.1%（+/- 8.2）。治疗后一个月，大鼠在8臂径向迷宫上进行顺序记忆任务训练。在试验的几天里，接受MET治疗的大鼠在迷宫序列中的手臂之间的直接运动显着减少。学习障碍与内侧纹状体DA耗竭程度以及纹状体5-羟色胺组织含量显着相关。仅内侧纹状体DA耗竭超过40%的大鼠表现出明显的损伤。这些结果提供了额外的证据，甲基苯丙胺诱导的学习障碍，并建议，这种损害是依赖于纹状体单胺损失，在一般情况下，和DA损失的程度，特别是在内侧纹状体。(C)2005年爱思唯尔公司All rights reserved.
Methamphetamine (METH) use results in depletion of monoamines in the striatum. The purpose of this study was to evaluate the relation between the degree of METH-induced monoamine depletion in the striatum and impairment on a striatally-dependent learning task in rats. Male Sprague-Dawley rats received four injections of METH (10 mg/kg) or saline at 2-h intervals. METH treatment produced a 38.5% (+/-5.6) and 46.7% (+/-6.7) dopamine (DA) depletion in the medial and lateral striatum, respectively. Serotonin (5-HT) was depleted 15.6% (+/- 10.4) and 21.1% (+/- 8.2) in the medial and lateral striatum, respectively. One month after treatment, rats were trained on a sequential-memory task on an 8-arm radial maze. METH-treated rats made significantly fewer direct movements between arms in the maze sequence across days of trials. The learning impairment was significantly correlated with the degree of DA depletion in the medial striatum, as well as serotonin tissue content in striatum. Only rats with a greater than 40% DA depletion in medial striatum showed significant impairments. These results provide additional evidence for METH-induced learning impairments and suggest that this impairment is dependent on the striatal monoamine loss, in general, and the degree of DA loss in medial striatum, in particular. (C) 2005 Elsevier Inc. All rights reserved.