Possible role of potentiators in radiation therapy.
Possible role of potentiators in radiation therapy.
复制标题
增强剂在放射治疗中的可能作用。
DOI：
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发表时间：
1961
期刊：
影响因子：
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通讯作者：
Bagshaw Ma
中科院分区：
文献类型：
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作者：
Bagshaw Ma
在视网膜母细胞瘤中，透射电子显微镜联合放射治疗对周围正常组织的损伤较小，治愈率较高。化疗药物增强X射线效应的可能性有很多。其中，氟尿嘧啶和放线菌素D的用处似乎有限。其他卤代嘧啶类似物如BUDR和IUDR的DNA掺入方式表明，这些化合物有望成为增效剂。建议进行更多的临床前研究，以选择最有可能在临床水平上成功的组合。为了证明通过化学强化可以提高伦琴治疗的疗效，有必要对患者进行长期研究，仔细挑选肿瘤类型。(身份验证)
In retinoblastoma a higher cure rate with less damage to the adjacent normal tissue was demonstrated when TEM was used in conjunction with roentagen radiation. Numerous possibilities for the potentiation of roentgen-ray effects by chemotherapeutic agents have been suggested. Among these, FU and actinomycin D appear to have limited usefulness. The mode of incorporation lnto DNA of other halogenated pyrimidine analogues such as BUDR and IUDR suggests that these compounds hold promise as potentiating agents. More pre-clinical investigation is indicated in order to select that combination most likely to succeed on a clinical level. In order to prove that the efficacy of roentgen therapy can be increased by chemical potentiation, a long-term study of patients, carefully selected as to neoplastic type, will be necesssry. (auth)