Mycobacterial lipomannan induces matrix metalloproteinase-9 expression in human macrophagic cells through a Toll-like receptor 1 (TLR1)/TLR2- and CD14-dependent mechanism
Mycobacterial lipomannan induces matrix metalloproteinase-9 expression in human macrophagic cells through a Toll-like receptor 1 (TLR1)/TLR2- and CD14-dependent mechanism
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DOI：
10.1128/iai.73.10.7064-7068.2005
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发表时间：
2005-10-01
影响因子：
3.1
通讯作者：
Kremer, L
中科院分区：
文献类型：
--
作者：
Elass, E;Aubry, L;Kremer, L
各种分枝杆菌的脂甘露聚糖(LM)可诱导人巨噬细胞样分化的THP-1细胞和原代人巨噬细胞表达和分泌基质金属蛋白酶9(MMP9)。使用抗受体中和抗体的抑制研究表明，Toll样受体1(TLR1)/TLR2-和CD14依赖的信号机制。此外，LM还下调了金属蛋白酶抑制剂TIMP-1的转录，TIMP-1是一种主要的内源性基质金属蛋白酶-9调节因子。
Lipomannans (LM) from various mycobacterial species were found to induce expression and secretion of the matrix metalloproteinase 9 (MMP-9) both in human macrophage-like differentiated THP-1 cells and in primary human macrophages. Inhibition studies using antireceptor-neutralizing antibodies are indicative of a Toll-like receptor 1 (TLR1)/TLR2- and CD14-dependent signaling mechanism. Moreover, LM was shown to down-regulate transcription of the metalloproteinase inhibitor TIMP-1, a major endogenous MMP-9 regulator.