The function of SARI in modulating epithelial-mesenchymal transition and lung adenocarcinoma metastasis.
The function of SARI in modulating epithelial-mesenchymal transition and lung adenocarcinoma metastasis.
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SARI 在调节上皮间质转化和肺腺癌转移中的作用
DOI：
10.1371/journal.pone.0038046
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Hao X
中科院分区：
文献类型：
--
作者：
Wang C;Su Y;Zhang L;Wang M;You J;Zhao X;Zhang Z;Liu J;Hao X
SARI （AP-1的抑制因子，由IFN调节）基因，也被称为BATF2，与几种癌症的风险相关，并且在侵袭性和转移性癌症中经常检测到SARI表达的缺失。然而，SARI在肺腺癌中的功能作用尚不清楚。我们已经证明，SARI表达的缺失会引发上皮-间质转化（EMT），这可以通过肺腺癌细胞系和临床肺腺癌标本中E-cadherin的抑制和vimentin的上调来观察。通过人肺异种移植-小鼠模型，我们观察到敲除人癌细胞中的内源性SARI可导致多发淋巴结转移的发展。此外，我们发现SARI是通过调节(GSK)-3β-β-catenin信号通路调控EMT的关键蛋白。这些结果证明了SARI在EMT中的作用机制，并提示评估SARI可能作为肺腺癌转移的预后生物标志物和潜在的治疗靶点。
The SARI (suppressor of AP-1, regulated by IFN) gene, which is also called BATF2, is associated with the risk of several kinds of cancer, and loss of SARI expression is frequently detected in aggressive and metastatic cancer. However, the functional role of SARI in lung adenocarcinoma remains unknown. We have shown that loss of SARI expression initiates epithelial-mesenchymal transition (EMT), which is visualized by repression of E-cadherin and up-regulation of vimentin in lung adenocarcinoma cell lines and in clinical lung adenocarcinoma specimens. Using a human lung xenograft-mouse model, we observed that knocking down endogenous SARI in human carcinoma cells leads to the development of multiple lymph node metastases. Moreover, we showed that SARI functions as a critical protein in regulating EMT by modulating the (GSK)-3β-β-catenin signaling pathway. These results demonstrate the mechanism of SARI function in EMT and suggest that assessment of SARI may serve as a prognostic biomarker and potential therapeutic target for lung adenocarcinoma metastasis.
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影响因子：
3.8
作者：
Li J;Zhou BP
通讯作者：
Zhou BP
影响因子：
11.1
作者：
Maschler, Sabine;Gebeshuber, Christoph A.;Wiedemann, Eva-Maria;Alacakaptan, Memetcan;Schreiber, Martin;Custic, Ivana;Beug, Hartmut
通讯作者：
Beug, Hartmut
影响因子：
8
作者：
Dash, R.;Su, Z-Z;Fisher, P. B.
通讯作者：
Fisher, P. B.
影响因子：
64.8
作者：
通讯作者：
--
DOI：
10.1073/pnas.0807975106
发表时间：
2008-12-30
影响因子：
11.1
作者：
Su, Zao-Zhong;Lee, Seok-Geun;Fisher, Paul B.
通讯作者：
Fisher, Paul B.