Magnetic resonance imaging applications in the evaluation of tumor angiogenesis.
Magnetic resonance imaging applications in the evaluation of tumor angiogenesis.
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DOI：
10.1053/srao.2001.18105
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发表时间：
2001
影响因子：
3.5
通讯作者：
M. Neeman;J. Provenzale;M. Dewhirst
中科院分区：
文献类型：
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作者：
M. Neeman;J. Provenzale;M. Dewhirst
血管生成，即新血管的生长，是实体瘤发展的关键组成部分。在过去的十年中，血管生成生物学研究的进展已经导致鉴定出大量促进、参与和调节正常组织和肿瘤中新血管生长的分子。因此，已经鉴定了许多抑制血管生成的新靶点，并且现在处于临床试验中的不同开发和评估阶段。磁共振成像（MRI）提供了一个有吸引力的工具，在体内分析的基础生物学的血管生成，临床前评价的活动，一些潜在的抗血管生成剂，以及临床检测，诊断和预后。MRI的特征之一是可以成像血管生成的广泛生理参数。本文综述了血管生成的生物学基础，重点介绍了可用于成像的新血管系统的特征，随后概述了正在评估用于肿瘤血管生成分析的MRI方法。
Angiogenesis, the growth of new blood vessels, is a critical component in the development of solid tumors. Over the last decade, progress in the study of the biology of angiogenesis has led to identification of a large number of molecules that promote, participate, and regulate the growth of new vessels in normal tissue and in tumors. Consequently, many new targets for suppression of angiogenesis have been identified and are now at various stages of development and evaluation in clinical trials. Magnetic resonance imaging (MRI) provides an attractive tool for in vivo analysis of the basic biology of angiogenesis, for preclinical evaluation of the activity of a number of potential antiangiogenic agents, as well as for clinical detection, diagnosis, and prognosis. One of the features of MRI is the wide range of physiologic parameters by which angiogenesis can be imaged. This review presents the biological basis of angiogenesis with emphasis on characteristics of the neovasculature that can be used for imaging, followed by an overview of the MRI approaches that are being evaluated for the analysis of tumor angiogenesis.