Building capacity for collaborative research on opioid and other substance use disorders through the Clinical and Translational Science Award Program
Building capacity for collaborative research on opioid and other substance use disorders through the Clinical and Translational Science Award Program
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DOI：
10.1017/cts.2019.441
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发表时间：
2020-04-01
影响因子：
2.6
通讯作者：
Brady, Kathleen
中科院分区：
文献类型：
--
作者：
Cottler, Linda B.;Green, Alan I.;Brady, Kathleen
美国的阿片类药物危机需要通过临床和转化研究立即采取行动。通过国家药物滥用研究所（NIDA）和国家促进转化科学中心（NCATS）的资助已经建立的网络基础设施为实施以阿片类药物为重点的研究提供了重大优势，这些研究可以共同解决这一危机。NIDA支持培训赠款和临床试验网络; NCATS资助临床和转化科学奖（CTSA）计划，拥有50多个NCATS学术研究中心，用于区域临床和转化研究。总之，有独特的能力，临床研究，生物信息学，数据科学，社区参与，监管科学，机构合作伙伴关系，培训和职业发展，以及其他关键的翻译元素。CTSA中心为地方、区域和国家卫生危机提供前所未有的及时响应，以解决研究差距[临床和转化科学奖计划，领先创新与合作中心，协同论文申请]。本文描述了在CTSA中心开展阿片类药物合作研究的机会，以及随着危机的发展，建立最佳实践能力的NIDA-NCATS机会。景观调查（63个枢纽）的结果提供了最佳做法和合作的想法，与枢纽进行的研究也参与了总理NIDA倡议的描述。这种合作可以对阿片类药物的流行做出快速反应，同时在多个学科领域推进科学。
The opioid crisis in the USA requires immediate action through clinical and translational research. Already built network infrastructure through funding by the National Institute on Drug Abuse (NIDA) and National Center for Advancing Translational Sciences (NCATS) provides a major advantage to implement opioid-focused research which together could address this crisis. NIDA supports training grants and clinical trial networks; NCATS funds the Clinical and Translational Science Award (CTSA) Program with over 50 NCATS academic research hubs for regional clinical and translational research. Together, there is unique capacity for clinical research, bioinformatics, data science, community engagement, regulatory science, institutional partnerships, training and career development, and other key translational elements. The CTSA hubs provide unprecedented and timely response to local, regional, and national health crises to address research gaps [Clinical and Translational Science Awards Program, Center for Leading Innovation and Collaboration, Synergy paper request for applications]. This paper describes opportunities for collaborative opioid research at CTSA hubs and NIDA-NCATS opportunities that build capacity for best practices as this crisis evolves. Results of a Landscape Survey (among 63 hubs) are provided with descriptions of best practices and ideas for collaborations, with research conducted by hubs also involved in premier NIDA initiatives. Such collaborations could provide a rapid response to the opioid epidemic while advancing science in multiple disciplinary areas.