Neuronal Mitophagy: Long-Distance Delivery or Eating Locally?

Neuronal Mitophagy: Long-Distance Delivery or Eating Locally?
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DOI:
10.1016/j.cub.2014.09.037
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发表时间:
2014-10
期刊:
影响因子:
9.2
通讯作者:
B. Lu
B. Lu
中科院分区:
生物学1区
文献类型:
--
作者:
B. Lu

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帕金森病相关的 PINK1 和 Parkin 通过促进非神经元细胞中的线粒体自噬(自噬清除受损线粒体)来维持线粒体健康。它们是否在神经元中发挥作用一直存在争议。一项新的研究旨在解决这一争议。
Parkinson's disease-associated PINK1 and Parkin maintain mitochondrial health through promoting mitophagy, the autophagic removal of damaged mitochondria, in non-neuronal cells. Whether they do so in neurons has been controversial. A new study aims to resolve the controversy.