Distribution of slow myosin in dystrophic chicken muscle.
Distribution of slow myosin in dystrophic chicken muscle.
复制标题
营养不良鸡肌肉中慢肌球蛋白的分布。
DOI：
10.1007/978-1-4684-4907-5_5
复制
发表时间：
1985
影响因子：
--
通讯作者：
Bandman,E
中科院分区：
文献类型：
--
作者：
Bandman,E
禽肌营养不良症是一种优先影响快缩肌发育的疾病（215，218）。以前的研究使用解剖学、组织化学和生物化学方法证明，后背阔肌（PLD）存在明显的营养不良异常，而前背阔肌（ALD）是一种缓慢的强直性肌肉，不受疾病影响（216，219）。这项研究的大部分是在不同遗传背景的正常鸡和营养不良鸡上进行的。虽然禽肌营养不良症是由一个常染色体隐性基因引起的，但在新罕布什尔州的背景下，该营养不良基因可引起相对较快的肌纤维萎缩（217，220）。这些影响很可能是由于两个品种的肌肉生长速度不同。由于现在存在正常和营养不良鸡的近交系，其包含超过90%的共同基因，因此将这些品系（正常品系03和营养不良品系433）用于本研究，以确保在正常和营养不良肌肉之间观察到的差异是由于疾病引起的。
Avian muscular dystrophy is a disorder that preferentially affects the development of fast twitch muscles (215,218). Previous research using anatomical, histochemical, and biochemical methods have demonstrated clear dystrophic abnormalities in the posterior latisslmus dorsi (PLD) while the anterior latissimus dorsi (ALD), a slow tonic muscle, is unaffected by the disease (216,219). Most of this research has been performed on normal and dystrophic chickens of different genetic backgrounds. While avian muscular dystrophy is caused by a single autosomal recessive gene, the dystrophic gene causes relatively rapid fiber atrophy when placed on a New Hampshire background (217,220). These effects are most likely due to differences in the rate of muscle growth in the two breeds. Since inbred lines of normal and dystrophic chickens now exist that contain greater than 90% of their genes in common, these strains (normal line 03 and dystrophic line 433) were used for the current study to ensure that the differences observed between normal and dystrophic muscles were due to the disease.