Unilateral deficits in visual perception and learning after unilateral inferotemporal cortex lesions in macaques.
Unilateral deficits in visual perception and learning after unilateral inferotemporal cortex lesions in macaques.
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猕猴单侧颞下皮层损伤后单侧视觉感知和学习缺陷。
DOI：
10.1093/cercor/bhh045
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发表时间：
2004
期刊：
影响因子：
--
通讯作者：
Saunders,RichardC
中科院分区：
文献类型：
--
作者：
Merigan,WilliamH;Saunders,RichardC
本研究采用局部病变结合控制固定的方法，研究了猕猴颞下皮层的感知作用。在3只猴子的IT皮质上做单侧病变，不切除胼胝体，在病变的同侧和对侧测试视觉功能。观察到的变化与一只猴子的双侧IT皮质损伤的影响进行了比较，这是之前大多数研究中使用的方法。与双侧病变相比，单侧病变对测试视力的影响远没有双侧病变严重，但更具选择性。单侧病变的三只猴子均表现出色觉敏感度下降，但消色觉敏感度保留，严重破坏了学习和对样本的视觉匹配能力，并且在所有情况下，视觉丧失都发生在病变部位的对侧。出乎意料的是，其中一只猴子的胼胝体和前连合的后期切除并没有增加对侧损失的程度，这种损伤会消除同侧颞叶皮层神经元向对侧的半球间输入。这些结果支持了生理学上的发现，即尽管许多IT神经元接受双侧激活，但IT皮层神经元的反应是由对侧视野主导的。与早期对向IT皮层提供输入的V4区病变的研究相比，V4区与IT区病变产生的效果有质的不同。
This study adapted the method of partial lesions, combined with controlled fixation, to study the perceptual role of macaque inferotemporal (IT) cortex. Unilateral lesions were made in IT cortex of three monkeys, without section of the corpus callosum, and visual function was tested ipsilateral and contralateral to the lesion. The observed changes were compared to the effects of bilateral lesions of IT cortex in one monkey, the approach used in most previous studies. Unilateral lesions produced far less profound, although more selective, loss on the tested visual abilities than did bilateral lesions. All three monkeys with unilateral lesions showed decreased chromatic sensitivity, but sparing of achromatic sensitivity, and severely disrupted learning and performance of visual matching to sample, and in all cases, the visual loss was contralateral to the site of the lesion. Unexpectedly, the magnitude of the contralateral loss was not increased by later section of the corpus callosum and anterior commissure in one of the monkeys, a lesion that removes interhemisperic input to contralateral from ipsilateral temporal cortex neurons. These results support physiological findings that show that the response of IT cortex neurons is dominated by the contralateral visual field, despite the bilateral activation many IT neurons receive. Comparison to earlier studies of lesions of area V4, which provides input to IT cortex, shows that V4 and IT lesions produce qualitatively different effects.
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作者：
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DOI：
--
发表时间：
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期刊：
Journal of Comparative and Physiological Psychology
影响因子：
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作者：
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