Regulation of cap-dependent translation by eIF4E inhibitory proteins
Regulation of cap-dependent translation by eIF4E inhibitory proteins
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DOI：
10.1038/nature03205
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发表时间：
2005-02-03
期刊：
影响因子：
64.8
通讯作者：
Sonenberg, N
中科院分区：
文献类型：
--
作者：
Richter, JD;Sonenberg, N
真核信使RNA在其50末端含有修饰的鸟苷，称为帽。mRNA的翻译需要起始因子eIF4E与帽结构的结合。在这里，我们描述了一个家庭的蛋白质，通过一个共同的序列调节帽依赖性翻译。这种翻译调节的生物学重要性是巨大的，并影响细胞生长，发育，致癌转化，甚至可能轴突寻路和记忆巩固等过程。
Eukaryotic messenger RNAs contain a modified guanosine, termed a cap, at their 50 ends. Translation of mRNAs requires the binding of an initiation factor, eIF4E, to the cap structure. Here, we describe a family of proteins that through a shared sequence regulate cap-dependent translation. The biological importance of this translational regulation is immense, and affects such processes as cell growth, development, oncogenic transformation and perhaps even axon pathfinding and memory consolidation.