PHOTODYNAMIC THERAPY OF EXPERIMENTAL CHOROIDAL NEOVASCULARIZATION USING LIPOPROTEIN-DELIVERED BENZOPORPHYRIN
PHOTODYNAMIC THERAPY OF EXPERIMENTAL CHOROIDAL NEOVASCULARIZATION USING LIPOPROTEIN-DELIVERED BENZOPORPHYRIN
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DOI：
10.1001/archopht.1995.01100060136048
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发表时间：
1995-06-01
影响因子：
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通讯作者：
GRAGOUDAS, ES
中科院分区：
文献类型：
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作者：
MILLER, JW;WALSH, AW;GRAGOUDAS, ES
目的：目的：探讨苯并卟啉衍生物单酸（Verteporfin）光动力学疗法对实验性脉络膜新生血管的治疗作用。在静脉注射与低密度脂蛋白复合的苯并卟啉衍生物单酸（1至2 mg/kg）后，用692 nm的光照射眼睛，能量密度为50至150 J/cm（2），辐照度为150至600 mW/cm（2）。结果：光动力治疗后，脉络膜新生血管内血管闭塞，脉络膜新生血管内皮和脉络膜下脉络膜毛细血管受损，脉络膜新生血管内皮和脉络膜下脉络膜毛细血管均被破坏。结论：脂蛋白介导的苯并卟啉衍生物单酸光动力学疗法对脉络膜新生血管的动物模型有效，可能是一种有前景的、潜在的选择性治疗脉络膜新生血管的方法。
Objective: To investigate photodynamic therapy of experimental choroidal neovascularization using benzoporphyrin derivative monoacid (Verteporfin).Methods: Photodynamic therapy using benzoporphyrin derivative monoacid was investigated in cynomolgus monkeys. Following intravenous injection of benzoporphyrin derivative monoacid (1 to 2 mg/kg) complexed with low-density lipoprotein, the eyes were irradiated with 692-nm light at a fluence of 50 to 150J/cm(2) and irradiance of 150 to 600 mW/cm(2). Choroidal neovascularization was documented before photodynamic therapy and closure was demonstrated by fundus photography, fluorescein angiography, and right and electron microscopic examination.Results: Following photodynamic therapy, vessels within choroidal neovascularization were occluded, and there was damage to the choroidal neovascularization endothelium and the subjacent choriocapillaris. Damage to the retinal pigment epithelium and photoreceptors was also observed.Conclusion: Photodynamic therapy with lipoprotein delivered benzoporphyrin derivative monoacid was effective in this animal model of choroidal neovascularization and may be a promising, potentially selective, therapy for choroidal neovascularization.