Treponema denticola in disseminating endodontic infections
Treponema denticola in disseminating endodontic infections
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DOI：
10.1177/154405910608500814
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发表时间：
2006-08-01
影响因子：
7.6
通讯作者：
Stashenko, P.
中科院分区：
文献类型：
--
作者：
Foschi, F.;Izard, J.;Stashenko, P.
齿垢密螺旋体是一种公认的牙周病原体，最近被认为与牙髓病理学有关。本研究观察了T。与多微生物的“红色复合体”生物体（RC）（牙龈卟啉单胞菌（Porphyromonas gingivalis）、Tannerella gingthia和T.分析了在野生型（WT）和严重联合免疫缺陷（SCID）小鼠中诱导播散性感染的作用。21天后，在单独感染T.而在感染红色复合体的SCID小鼠或野生型小鼠中，寄生虫很少。脾肿大存在于所有组中，但只有单一感染的SCID小鼠体重减轻。T.在单一感染的SCID小鼠的脾、心脏和脑中以及在单一感染的野生型小鼠的脾中检测到齿垢DNA，所述野生型小鼠也具有更多的根尖周骨吸收。结果表明，T.齿垢具有高致病性，包括传播到远处器官，进一步证实了其在口腔和相关全身性疾病中的潜在重要性。
Treponema denticola is a consensus periodontal pathogen that has recently been associated with endodontic pathology. In this study, the effect of mono-infection of the dental pulp with T. denticola and with polymicrobial "red-complex" organisms (RC) (Porphyromonas gingivalis, Tannerella forsythia, and T. denticola) in inducing disseminating infections in wild-type (WT) and severe-combined-immunodeficiency (SCID) mice was analyzed. After 21 days, a high incidence (5/10) of orofacial abscesses was observed in SCID mice mono-infected with T. denticola, whereas abscesses were rare in SCID mice infected with the red-complex organisms or in wild-type mice. Splenomegaly was present in all groups, but only mono-infected SCID mice had weight loss. T. denticola DNA was detected in the spleen, heart, and brain of mono-infected SCID mice and in the spleen from mono-infected wildtype mice, which also had more periapical bone resorption. The results indicate that T. denticola has high pathogenicity, including dissemination to distant organs, further substantiating its potential importance in oral and linked systemic conditions.