Influenza virus "A" infections of Cynomolgus monkeys
Influenza virus "A" infections of Cynomolgus monkeys
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DOI：
10.1038/icb.1941.43
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发表时间：
1941-01-01
期刊：
影响因子：
--
通讯作者：
BURNET, F. M.
中科院分区：
文献类型：
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作者：
BURNET, F. M.
食蟹猴（Macacus病毒）易感染甲型流感病毒株，如果病毒在气管内注射。采用羊膜途径接种的鸡胚羊水和尿囊液作为接种剂。一种菌株（“W. S. Egg”）产生了一系列致命感染，没有证据表明除病毒外还涉及任何其他病原体。感染主要累及小细支气管的上皮，鼻腔和大支气管的上皮未见组织学损伤。对原发性有症状感染和继发性无症状再感染都有积极的血清学反应。两只反复气管内接种人流感病毒株的猴子产生了高滴度的抗“猪”流感病毒抗体；在有限系列的免疫专家。最显著的特征是抗体水平与感染抵抗力之间的相关性。摘要作者：F. M. Burnet
Cynomolgus monkeys (Macacus irus) are susceptible to infection with influenza virus A strains if virus is administered in high conc, intratracheally. Amniotic and allantoic fluids from chick embryos inoculated by the amniotic route were used as inocula. With one strain ("W. S. Egg") a series of fatal infections was produced without evidence that any other pathogen than the virus was involved. The infection involves predominantly the epithelium of the smaller bronchioles, the epithelium of the nasal cavity and larger bronchi showing no histological evidence of damage. There is an active serological response both to primary symptomatic infections and to secondary symptomless reinfections. Two monkeys given repeated intratracheal inoculations of human strains developed high titre antibody against "Swine" influenza virus; in a limited series of immunization expts. the most significant feature was the correlation between antibody level and resistance to infection. || ABSTRACT AUTHORS: F. M. Burnet