Effect of granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor on polymorphonuclear neutrophils, monocytes or monocyte-derived macrophages combined with voriconazole against Cryptococcus neoformans
Effect of granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor on polymorphonuclear neutrophils, monocytes or monocyte-derived macrophages combined with voriconazole against Cryptococcus neoformans
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DOI：
10.1080/714031074
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发表时间：
2002-02-01
期刊：
影响因子：
2.9
通讯作者：
Stevens, DA
中科院分区：
文献类型：
--
作者：
Chiller, T;Farrokhshad, K;Stevens, DA
在体外试验中，观察了伏立康唑（VCZ）对新生隐球菌（Cn）的抗真菌活性，并与中性粒细胞（PMN）、单核细胞和单核细胞衍生的巨噬细胞（MDM）进行了比较。将添加和不添加VCZ的人效应细胞与Cn孵育24小时。PMN、mono和MDM单独作用时，对Cn的抑制率分别为61%、34%和23%（n = 3，P
The antifungal activity of voriconazole (VCZ) was tested against Cryptococcus neoformans (Cn) with and without the addition of polymorphonuclear neutrophils (PMN), monocytes or monocyte-derived macrophages (MDM) in vitro. Human effector cells with and without the addition of VCZ were incubated with Cn for 24 h. PMN, mono and MDM alone resulted in 61%, 34% and 23% inhibition of Cn, respectively (n = 3, P