High-altitude physiology and pathophysiology: implications and relevance for intensive care medicine.
High-altitude physiology and pathophysiology: implications and relevance for intensive care medicine.
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高海拔生理学和病理生理学：对重症监护医学的影响和相关性。
DOI：
10.1186/cc5142
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发表时间：
2007
期刊：
影响因子：
--
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中科院分区：
文献类型：
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细胞缺氧是危重病人损伤的一个基本机制。对人体对低气压引起的缺氧反应的研究定义了高原医学和生理学的领域。一种新的范式表明，对极端环境挑战（例如，低气压、缺氧、超高压、微重力、冷、热）的生理和病理生理反应可能与危重疾病中的反应相似。本综述探讨了人类对高海拔缺氧的反应可能被用作探索危重疾病病理生理因素的一种手段。
Cellular hypoxia is a fundamental mechanism of injury in the critically ill. The study of human responses to hypoxia occurring as a consequence of hypobaria defines the fields of high-altitude medicine and physiology. A new paradigm suggests that the physiological and pathophysiological responses to extreme environmental challenges (for example, hypobaric hypoxia, hyper-baria, microgravity, cold, heat) may be similar to responses seen in critical illness. The present review explores the idea that human responses to the hypoxia of high altitude may be used as a means of exploring elements of the pathophysiology of critical illness.