COCAINE-INDUCED ROTATION - SEX-DEPENDENT DIFFERENCES BETWEEN LEFT-SIDED AND RIGHT-SIDED RATS
COCAINE-INDUCED ROTATION - SEX-DEPENDENT DIFFERENCES BETWEEN LEFT-SIDED AND RIGHT-SIDED RATS
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DOI：
10.1126/science.6879177
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发表时间：
1983-01-01
期刊：
影响因子：
56.9
通讯作者：
SHAPIRO, RM
中科院分区：
文献类型：
--
作者：
GLICK, SD;HINDS, PA;SHAPIRO, RM
可卡因在本地大鼠中引起剂量相关旋转（盘旋）。最大效应大于以前观察到的其他药物。女性比男性对可卡因更敏感。偏右的女性比偏左的女性更敏感，偏左的男性比偏右的男性更敏感。大脑不对称性的性别差异可能是可卡因敏感性的重要决定因素。
Cocaine elicited dose-related rotation (circling) in native rats. The maximum effect was greater than observed previously with other drugs. Females were more sensitive to cocaine than males. Right-biased females were more sensitive than left-biased females; left-biased males were more sensitive than right-biased males. Sex-dependent differences in brain asymmetry may be important determinant of cocaine sensitivity.