The role of cancer stem cells in the modulation of anti-tumor immune responses.
The role of cancer stem cells in the modulation of anti-tumor immune responses.
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DOI：
10.1016/j.semcancer.2018.09.006
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发表时间：
2018-12
影响因子：
14.5
通讯作者：
Ferrone S
中科院分区：
文献类型：
--
作者：
Maccalli C;Rasul KI;Elawad M;Ferrone S
肿瘤病变包括多个细胞亚群，包括具有“干性”性质的那些。后一种细胞负责肿瘤起始、转移形成、对常规疗法的抗性和疾病复发。这些相对罕见的细胞被称为癌症干细胞（CSC）或癌症起始细胞（CIC），其定义基于自我更新，多能性和致瘤性。这些细胞通过其免疫调节功能可以逃避免疫监视，以静止和休眠的形式持续存在。它们可以驱动肿瘤生长和复发，即使在长时间的潜伏期之后。此外，CSC/CIC由于其调节和塑造免疫反应的能力，可以代表导致癌症患者免疫治疗耐药性的肿瘤成分。本文综述了CSCs/CICs的免疫学特性，特别关注T细胞介导的免疫应答的调节机制。需要进一步剖析调节CSC/CIC的免疫学特征及其与免疫细胞和肿瘤微环境的相互作用的机制进行了讨论。CSC/CIC的免疫学特性的改进表征将有助于靶向这些细胞的免疫干预的合理设计，并可能导致恶性疾病的根除。
Tumor lesions comprise multiple subpopulations of cells including those endowed with “stemness” properties. The latter cells are responsible of tumor initiation, metastasis formation, resistance to conventional therapies and disease recurrence. These relatively rare cells denominated cancer stem cells (CSCs) or cancer initiating cells (CICs) are defined based on self-renewing, multipotency and tumorigenicity. These cells through their immunomodulating features can evade from immunesurveillance, persisting in the form of quiescence and dormancy. They can drive the neoplastic growth and recurrence, even after long latency. Moreover, CSCs/CICs due to their ability to modulate and shape immune responses can represent the component of a tumor causing immunotherapy resistance in cancer patients. In this review a general overview of immunological properties of CSCs/CICs is provided, with a special focus on the mechanisms of modulation of T cell mediated responses. The need to further dissect the mechanisms regulating the immunological profile of CSCs/CICs and their interactions with immune cells and tumor microenvironment is discussed. An improved characterization of the immunological properties of CSCs/CICs will contribute to the rationale design of immunotherapeutic interventions which target these cells and may lead to the eradication of malignant diseases.
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影响因子：
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通讯作者：
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影响因子：
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DOI：
10.1158/1078-0432.ccr-15-0428
发表时间：
2015-09-15
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
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Jensen MC
DOI：
10.1158/1078-0432.ccr-11-1669
发表时间：
2012-04-15
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
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作者：
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通讯作者：
Jensen MC