iPfam:: visualization of protein-protein interactions in PDB at domain and amino acid resolutions
iPfam:: visualization of protein-protein interactions in PDB at domain and amino acid resolutions
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DOI：
10.1093/bioinformatics/bti011
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发表时间：
2005-02-01
期刊：
影响因子：
5.8
通讯作者：
Bateman, A
中科院分区：
文献类型：
--
作者：
Finn, RD;Marshall, M;Bateman, A
有许多资源包含关于蛋白质之间二元相互作用的信息。然而，蛋白质相互作用仅由任何蛋白质中的残基子集定义。我们已经实现了一个网络资源，允许在Pfam结构域和氨基酸残基的水平上的蛋白质数据库结构中的蛋白质相互作用的调查。这种详细的知识依赖于这样一个事实，即有大量的多结构域蛋白质和蛋白质复合物被存放在结构数据库中。名为iPfam的资源托管在Pfam英国网站内。大多数资源集中在蛋白质之间的相互作用; iPfam包括这些以及单个蛋白质中结构域之间的相互作用。
There are many resources that contain information about binary interactions between proteins. However, protein interactions are defined by only a subset of residues in any protein. We have implemented a web resource that allows the investigation of protein interactions in the Protein Data Bank structures at the level of Pfam domains and amino acid residues. This detailed knowledge relies on the fact that there are a large number of multidomain proteins and protein complexes being deposited in the structure databases. The resource called iPfam is hosted within the Pfam UK website. Most resources focus on the interactions between proteins; iPfam includes these as well as interactions between domains in a single protein.