A broad internalizing dimension accounts for the genetic associations between personality and individual internalizing disorders.
A broad internalizing dimension accounts for the genetic associations between personality and individual internalizing disorders.
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DOI：
10.1037/abn0000782
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发表时间：
2022-11
期刊：
影响因子：
--
通讯作者：
Waldman, Irwin D
中科院分区：
文献类型：
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作者：
Poore, Holly E;Watts, Ashley L;Friedman, Hannah P;Waldman, Irwin D
许多研究表明，精神病理学可以用广泛的维度来描述，代表多种精神疾病的倾向。广泛的精神病理学（例如，内化和外化）越来越多地被用作调查精神病理学的发展、病因学和过程的研究的目标，因为它们解释了曾经被假定为不同的障碍之间的相关性模式。因此，这些光谱代表诱人的目标，由于其全面和简约的性质。尽管如此，很少有研究确定个体疾病在精神病理学研究中超出广泛维度的作用。在目前的研究中，我们调查是否有独特的病因学之间的关联个人内化障碍和人格特质后，占其病因学协会与广泛的内化维度。我们使用了一个社区样本的双胞胎（Npairs = 448）4-19岁，以检查内在的精神病理学和大5人格维度之间的病因学关联。在遗传协变方面，广泛的内在化维度与神经质呈正相关，与外向性、宜人性和外向性呈负相关。此外，内化解释了个体内化障碍和人格特质之间共享的大部分遗传变异。然而，以下几对人格特征和疾病之间存在独特的遗传关联：神经质和社交焦虑，外向性和社交焦虑，宜人性和抑郁，以及强迫性和强迫性。几乎没有证据表明内化和人格之间存在环境影响。总之，广泛的内化维度足以解释几乎所有的内化障碍和人格之间的病因协变，有几个有趣的例外。这项研究表明，一个广泛的内化维度，这代表了经历各种情绪和焦虑障碍的责任，解释了人格特质和内化障碍之间共享的遗传和环境影响。这一发现支持使用广泛的，transdiagnosis维度的精神病理学作为目标的病因，过程和治疗的精神病理学的研究。
Much research has demonstrated that psychopathology can be described in terms of broad dimensions, representing liability for multiple psychiatric disorders. Broad spectra of psychopathology (e.g., internalizing and externalizing) are increasingly used as targets for research investigating the development, etiology, and course of psychopathology because they account for patterns of relatedness among disorders that were once presumed distinct. Thus, these spectra represent alluring targets due to their comprehensive and parsimonious nature. Nevertheless, little research has established the role of individual disorders over and above broad dimensions in the study of psychopathology. In the current study, we investigate whether there are unique etiological associations between individual internalizing disorders and personality traits after accounting for their etiological associations with a broad internalizing dimension. We used a community sample of twins (Npairs = 448) ages 4–19 to examine the etiological associations between internalizing psychopathology and Big 5 personality dimensions. In terms of genetic covariation, a broad internalizing dimension was positively associated with neuroticism and negatively associated with extraversion, agreeableness, and conscientiousness. Moreover, internalizing accounted for most of the genetic variance shared between individual internalizing disorders and personality traits. Nevertheless, there were unique genetic associations between the following pairs of personality traits and disorders: neuroticism and social anxiety, extraversion and social anxiety, agreeableness and depression, and conscientiousness and compulsions. There was little evidence of environmental influences shared between internalizing and personality. In sum, a broad internalizing dimension adequately accounted for almost all of the etiologic covariation between internalizing disorders and personality, with several interesting exceptions. This study suggests that a broad internalizing dimension, which represents liability to experience a variety of mood and anxiety disorders, accounts for the genetic and environmental influences shared between personality traits and internalizing disorders. This finding supports the use of broad, transdiagnostic dimensions of psychopathology as targets in the study of the etiology, course, and treatment of psychopathology.