Gilles de la Tourette's syndrome and obsessive-compulsive disorder. Evidence supporting a genetic relationship.
Gilles de la Tourette's syndrome and obsessive-compulsive disorder. Evidence supporting a genetic relationship.
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DOI：
10.1001/archpsyc.1986.01800120066013
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发表时间：
1986-12
影响因子：
--
通讯作者：
D. Pauls;K. Towbin;J. Leckman;G. Zahner;D. Cohen
中科院分区：
文献类型：
--
作者：
D. Pauls;K. Towbin;J. Leckman;G. Zahner;D. Cohen
以前的研究表明，强迫症状经常出现在吉尔斯·德拉·图雷特综合征（TS）患者中。为了研究TS与强迫症（OCD）之间的关系，通过半结构化访谈获得了TS先证者的所有一级亲属的数据，旨在收集个体一生中是否存在TS、其他抽动障碍和神经精神疾病的信息。一级亲属的强迫症发生率明显高于一般人群和收养亲属的对照样本。先证者有强迫症（TS +/-强迫症）的家庭与无强迫症（TS -强迫症）的家庭相比，TS、强迫症和慢性多发性抽动症（CMT）的发病率几乎相同。最后，一级亲属中无TS或CMT的强迫症发生率在TS + OCD和TS - OCD先证家庭中均显著升高，这表明某些形式的强迫症可能代表了导致TS和/或CMT的因素的另一种表达。
Previous studies have suggested that obsessive-compulsive symptoms frequently occur among patients with Gilles de la Tourette's syndrome (TS). To examine the relationship between TS and obsessive-compulsive disorder (OCD), data from all first-degree relatives of TS probands were obtained with a semistructured interview designed to collect information on the presence of TS, other tic disorders, and neuropsychiatric illnesses during the lifetime of the individual. The rate of OCD among first-degree relatives was significantly increased over estimates from the general population and a control sample of adoptive relatives. The rates of TS, OCD, and chronic multiple tics (CMT) were virtually the same in families of probands with OCD (TS +/- OCD) when compared with families of probands without OCD (TS - OCD). Finally, the frequency of OCD without TS or CMT among first-degree relatives was significantly elevated in families of both TS + OCD and TS - OCD probands, suggesting that some forms of OCD may represent an alternative expression of the factors responsible for TS and/or CMT.