Association Between Dietary Fish and PUFA Intake in Midlife and Dementia in Later Life: The JPHC Saku Mental Health Study
Association Between Dietary Fish and PUFA Intake in Midlife and Dementia in Later Life: The JPHC Saku Mental Health Study
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DOI：
10.3233/jad-191313
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发表时间：
2021-01-01
影响因子：
4
通讯作者：
Tsugane, Shoichiro
中科院分区：
文献类型：
--
作者：
Nozaki, Shoko;Sawada, Norie;Tsugane, Shoichiro
背景：中年饮食习惯与痴呆风险之间的关系尚不清楚。目的：探讨中年饮食中鱼类与n-3多不饱和脂肪酸（PUFA）摄入量与老年痴呆风险的关系。方法：本基于人群的队列研究评估了1127名参与者（1995年年龄为45-64岁）的食物频率（1995年和2000年的平均摄入量）和认知（2014-2015年）。我们使用logistic回归分析计算了食用鱼类、富含PUFA的鱼类、总n-3 PUFA、总n-6 PUFA、PUFA类型和n-3/n-6 PUFA比率四分位数的痴呆和轻度认知障碍（MCI）诊断的比值比（or）。根据年龄调整了预估的ORs；性;教育;吸烟状态;饮酒频率；身体活动;有癌症、心肌梗死、糖尿病病史；和抑郁。结果：在第二组（OR = 0.43 (95% CI = 0.20-0.93)）、第三组（OR = 0.22 (95% CI = 0.09-0.54)）和最高四分位数（OR = 0.39 (95% CI = 0.18-0.86)）中观察到，与非痴呆症（MCI加认知正常）相比，痴呆的风险显著降低；二十碳五烯酸（EPA）的第三（OR = 0.39 (95% CI = 0.16-0.92)）和最高四分位数（OR = 0.44 (95% CI = 0.19-0.98)）；二十二碳六烯酸（DHA）的第二组（OR = 0.39 (95% CI= 0.18-0.84)）、第三组（OR = 0.30 (95% CI= 0.13-0.70)）和最高四分位数（OR = 0.28 (95% CI= 0.12-0.66)）；二十二碳五烯酸（DPA）的第三个（OR = 0.36 (95% CI= 0.16-0.85)）和最高的四分位数（OR = 0.42 (95% CI= 0.19-0.95)）。结论：中年多吃鱼可能有助于预防老年痴呆。
Background: The relationship between midlife dietary habits and risk of dementia remains unclear.Objective: To investigate the association between dietary fish and n-3 polyunsaturated fatty acid (PUFA) consumption in midlife and risk of dementia in later life.Methods: This population-based cohort study assessed food frequency (average intake in 1995 and 2000) and cognition (2014-2015) in 1,127 participants (aged 45-64 in 1995). We used logistic regression analyses to calculate odds ratios (ORs) for dementia and mild cognitive impairment (MCI) diagnoses for consumption quartiles of fish, PUFA-rich fish, total n-3 PUFAs, total n-6 PUFAs, types of PUFAs, and n-3/n-6 PUFA ratio. Estimated ORs were adjusted for age; sex; education; smoking status; alcohol consumption frequency; physical activity; histories of cancer, myocardial infarction, and diabetes mellitus; and depression.Results: Significantly reduced risks of dementia over non-dementia (MCI plus cognitively normal) were observed in the second (OR = 0.43 (95% CI = 0.20-0.93)), third (OR = 0.22 (95% CI = 0.09-0.54)), and highest quartiles (OR = 0.39 (95% CI = 0.18-0.86)) for fish; the third (OR = 0.39 (95% CI = 0.16-0.92)) and highest quartiles (OR = 0.44 (95% CI = 0.19-0.98)) for eicosapentaenoic acid (EPA); the second (OR = 0.39 (95% CI = 0.18-0.84)), third (OR = 0.30 (95% CI = 0.13-0.70)), and highest quartiles (OR = 0.28 (95% CI= 0.12-0.66)) for docosahexaenoic acid (DHA); and the third (OR = 0.36 (95% CI = 0.16-0.85)) and highest quartiles (OR = 0.42 (95% CI= 0.19-0.95)) for docosapentaenoic acid (DPA).Conclusion: High intake of fish in midlife might aid in preventing dementia.