Increased substantia nigra echogenicity correlated with visual hallucinations in Parkinson's disease: a Chinese population-based study
Increased substantia nigra echogenicity correlated with visual hallucinations in Parkinson's disease: a Chinese population-based study
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帕金森病患者黑质回声增强与幻视相关：一项基于中国人群的研究
DOI：
10.1007/s10072-019-04110-z
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发表时间：
2020-03-01
影响因子：
3.3
通讯作者：
Tian, Jinzhou
中科院分区：
文献类型：
--
作者：
Li, Ting;Shi, Jing;Tian, Jinzhou
作为一种无创性检查技术，经颅黑质超声（TCS）在帕金森病（PD）的诊断和临床表现方面的作用日益显现。本研究旨在进一步评价TCS对PD的临床诊断价值，并探讨其与视幻觉（VH）的关系。共招募了226名受试者，包括141名PD患者和85名对照。所有参与者均接受TCS。在PD患者中进行了一系列评定量表以评估运动和非运动症状。结果表明，172名受试者成功地进行了TCS评估。PD组SN面积大于对照组（P < 0.001）。受试者工作特征（ROC）曲线分析显示，较大SN回声大小的最佳截止值为23.5 mm（2）（灵敏度70.3%，特异性77.0%）。VH患者的SN面积较大（P = 0.019），非运动症状量表（NMSS）评分较高（P = 0.018）。Logistic回归分析显示SN强回声（OR = 4.227，P = 0.012）和NMSS评分（OR = 0.027，P = 0.042）是VH的独立预测因子。结论：TCS可作为帕金森病的辅助诊断工具。SN回声增强与帕金森病的VH相关，可能是因为脑干参与了VH的发病机制。需要进一步的研究来证实这些发现。
As a noninvasive technique, transcranial sonography (TCS) of substantia nigra (SN) has gradually showed its effectiveness not only in diagnosis but also in understanding clinical features of Parkinson's Disease (PD). This study aimed to further evaluate TCS for clinical diagnosis of PD, and to explore the association between sonographic manifestations and visual hallucinations (VH). A total of 226 subjects including 141 PD patients and 85 controls were recruited. All participants received TCS. A series of rating scales to evaluate motor and non-motor symptoms were performed in PD patients. Results showed that 172 subjects were successfully assessed by TCS. The area of SN was greater in PD patients than that in controls (P < 0.001). As receiver-operating characteristic (ROC) curve analysis showed, the best cutoff value for the larger SN echogenicity size was 23.5 mm(2) (sensitivity 70.3%, specificity 77.0%). Patients with VH had larger SN area (P = 0.019), as well as higher Non-Motor Symptoms Scale (NMSS) scores (P = 0.018). Moreover, binary logistic regression analysis indicated that SN hyperechogenicity (odds ratio = 4.227, P = 0.012) and NMSS scores (odds ratio = 0.027, P = 0.042) could be the independent predictors for VH. In conclusion, TCS can be used as an auxiliary diagnostic tool for Parkinson's disease. Increased SN echogenicity is correlated with VH in Parkinson's disease, possibly because the brain stem is involved in the mechanism in the onset of VH. Further studies are needed to confirm these findings.