COMPARISON OF THE ANTINOCICEPTIVE EFFECTS INDUCED BY ELECTROACUPUNCTURE AND TRANSCUTANEOUS ELECTRICAL NERVE-STIMULATION IN THE RAT
COMPARISON OF THE ANTINOCICEPTIVE EFFECTS INDUCED BY ELECTROACUPUNCTURE AND TRANSCUTANEOUS ELECTRICAL NERVE-STIMULATION IN THE RAT
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DOI：
10.3109/00207459209003283
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发表时间：
1992-01-01
影响因子：
2.2
通讯作者：
HAN, JS
中科院分区：
文献类型：
--
作者：
WANG, JQ;MAO, LM;HAN, JS
以辐射热诱发甩尾反射潜伏期作为伤害感受指数，比较两种不同外周调理刺激电针（EA）和经皮神经电刺激（TENS）引起的镇痛效果。通过在 S36 和 Sp6 穴位以低强度（1-2-3 mA）和三种不同频率（2、15 和 100 Hz）之一进行 EA 和 TENS 给药，产生甩尾潜伏期的平行升高。 EA 或 TENS 的镇痛效果具有缓慢启动和缓慢关闭的特性，并且在三个频率中的任何一个频率上都发现两者之间存在显着的线性相关性。全身盐酸纳洛酮（2 mg/kg）几乎完全和部分分别拮抗2和15 Hz EA或TENS诱导的镇痛，但未能影响100 Hz EA或TENS诱导的镇痛。对三种频率之一的 EA 刺激的耐受性会降低相应频率 TENS 引起的镇痛，反之亦然。这些数据表明：（a）在相同部位施加两种不同的外周调节刺激时，产生抗伤害作用没有显着差异；（b）共同的神经机制最有可能处理 EA 和 TENS 的镇痛作用。详细讨论了内源性阿片机制在不同频率 EA 和 TENS 镇痛管理中的参与。
The analgesic effects induced by two different kinds of peripheral conditioning stimulations, electroacupuncture (EA) and transcutaneous electrical nerve stimulation (TENS), were compared in the rat using the latency of radiant heat-evoked tail flick reflex as nociceptive index. The parallel elevations of withdrawal latency of tail flick were produced by EA and TENS administrations at the acupoints of S36 and Sp6 with low intensity (1-2-3 mA) and one of three different frequencies (2, 15 and 100 Hz). Analgesic effects of EA or TENS were characterized by slow-on and slow-off nature, and a significant linear correlation was found between both at any one of three frequencies. Systemic naloxone hydrochloride (2 mg/kg) almost completely and partially antagonized 2 and 15 Hz EA- or TENS-induced analgesia, respectively, but failed to affect those induced by 100 Hz EA or TENS. Tolerance to EA stimulation with one of three frequencies reduced the corresponding frequency TENS-induced analgesia and vice versa. These data indicate that: (a) there is no significant difference in producing antinociception for two different peripheral conditioning stimulations when applied at the same sites and (b) the common neural mechanisms most likely process the analgesic effects of EA and TENS. The involvement of (an) endogenous opiate mechanism in the management of different frequency EA and TENS analgesia is discussed in detail.