Further evidence that a supraphysiologic estradiol level during ovarian stimulation affects birthweight: findings of fresh and frozen embryo transfer with comparable estradiol levels on human chorionic gonadotropin trigger
Further evidence that a supraphysiologic estradiol level during ovarian stimulation affects birthweight: findings of fresh and frozen embryo transfer with comparable estradiol levels on human chorionic gonadotropin trigger
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卵巢刺激期间超生理雌二醇水平影响出生体重的进一步证据：新鲜和冷冻胚胎移植的发现，雌二醇水平对人绒毛膜促性腺激素触发具有可比性
DOI：
10.1080/09513590.2020.1811963
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发表时间：
2020-08-28
影响因子：
2
通讯作者：
Xu, Yanwen
中科院分区：
文献类型：
--
作者：
Luo, Lu;Jie, Huiying;Xu, Yanwen
摘要有研究报道，卵巢刺激过程中超生理水平的雌二醇（E2）可能与新鲜胚胎移植（ET）后的低出生体重有关，但刺激周期中高E2水平是否会通过冷冻ET影响出生体重仍存在争议。本研究旨在探讨卵巢刺激周期中超生理E2水平是否会影响后续FET妊娠婴儿的出生体重。在这项回顾性队列研究中，分析了2525例通过FET受孕的单胎和2668例通过新鲜ET受孕的单胎。在低水平和高水平E2组中，通过FET受孕的婴儿的出生体重和小于胎龄儿（SGA）发生率无显著差异。多因素分析显示，E2峰值水平不能预测通过FET受孕的婴儿的SGA。通过新鲜ET受孕的单胎婴儿比通过FET受孕的单胎婴儿有更高的SGA风险，即使在之前暴露于> 3000 pg/mL的高水平E2之后也是如此。我们的研究结果表明，SGA风险的增加至少部分是由于超生理性E2暴露于宫内环境的结果。
Abstract Studies have reported a supraphysiologic estradiol (E2) level during ovarian stimulation may be related to low birthweight after fresh embryo transfer (ET), but whether a high E2 level in the stimulation cycle affects birthweight via frozen ET remained controversial. The study was to investigate whether a supraphysiologic E2 level in ovarian stimulation cycle affects birth weight in infants conceived via subsequent FET. In this retrospective cohort study, 2525 singletons conceived via FET and 2668 singletons conceived via fresh ET were analyzed. The birthweight and incidences of small for gestational age (SGA) in infants conceived via FET in groups with low and high levels of E2 did not differ significantly. Multivariate analyses showed that the peak E2 level was not predictive of SGA in infants conceived via FET. Singletons conceived via fresh ET had a higher risk of SGA than those conceived via FET even after comparable previous exposure to a high level of E2 > 3000 pg/mL. Our study results indicated that the increased risk of SGA was at least partly a result of the supraphysiologic E2 exposure to the intrauterine environment.