Cytoskeletal control of growth and cell fate switching
Cytoskeletal control of growth and cell fate switching
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DOI：
10.1016/j.ceb.2009.08.001
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发表时间：
2009-12-01
影响因子：
7.5
通讯作者：
Ingber, Donald E.
中科院分区：
文献类型：
--
作者：
Mammoto, Akiko;Ingber, Donald E.
活细胞必须能够以高保真度和精确的空间控制在生长和分化之间切换，以确保正常的组织模式在胚胎中形成并在整个成年期维持。大多数关于细胞增殖的工作集中于阐明负责控制细胞周期进程的信号传导途径，所述细胞周期进程由细胞与可溶性生长因子和不溶性细胞外基质结合而触发。在这里，我们回顾最近的工作，这表明，机械张力依赖的细胞形状和细胞骨架结构的变化是同样重要的控制生长，以及细胞命运的转换。这种可溶性、不溶性和机械性信号之间的相互作用有助于解释负责组织形成的细胞行为如何在活组织的物理环境中被控制。
Living cells must be able to switch between growth and differentiation with high fidelity and precise spatial control to ensure that normal tissue patterns are formed in the embryo and maintained throughout adult life. Most work on cell proliferation focuses on elucidating the signaling pathways responsible for control of cell cycle progression that are triggered by cell binding to soluble growth factors and insoluble extracellular matrix. Here we review recent work, which has revealed that mechanical tension-dependent changes in cell shape and cytoskeletal structure are equally critical for control of growth, as well as cell fate switching. This interplay between soluble, insoluble, and mechanical cues helps to explain how cell behaviors responsible for tissue formation are controlled in the physical context of living tissues.