A kinetic analysis of CO release from a diiron hexacarbonyl complex promoted by amino acids
A kinetic analysis of CO release from a diiron hexacarbonyl complex promoted by amino acids
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氨基酸促进二铁六羰基络合物释放 CO 的动力学分析
DOI：
10.1039/c4nj00661e
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发表时间：
2014-12-01
影响因子：
3.3
通讯作者：
Liu, Xiaoming
中科院分区：
文献类型：
--
作者：
Chen, Limei;Jiang, Xiujuan;Liu, Xiaoming
采用一种水溶性六羰基二铁配合物(Fe-2{mu-SCH2CH(OH)CH2(OH)}(CO)(6)](1)作为一氧化碳释放分子（CO- rm）。一氧化碳的释放是通过氨基酸取代结合的一氧化碳而开始的。配合物1的分解动力学对配合物和氨基酸都是一级过程。其CO释放速率随氨基酸的不同而不同。研究了l -半胱氨酸乙酯盐酸盐、丙氨酸、γ -氨基丁酸、l -组氨酸、l -脯氨酸和谷氨酸钠6种氨基酸作为CO释放促进剂。在所研究的启动子中，谷氨酸钠对促进配合物1释放CO的效率最高。总的CO释放涉及多个不同机制的步骤，最初缓慢的CO释放过程随后加快。缓慢过程的持续时间与溶剂有关。在D2O和生理盐水中，这个缓慢的过程比在DMSO中持续的时间要长得多。对含有谷氨酸和l -半胱氨酸乙酯盐酸盐的系统的细胞毒性评估表明，所检测的氨基酸和氨基酸衍生物比半胱氨酸具有更强的细胞毒性。
A water-soluble diiron hexacarbonyl complex, (Fe-2{mu-SCH2CH(OH)CH2(OH)}(CO)(6)] (1), was employed as a carbon monoxide releasing molecule (CO-RM). The CO release was initiated via substitution of the bound CO by amino acids. The kinetics of the decomposition of complex 1 was a first-order process with respect to both the complex and amino acids. Its rate of CO release varies with the amino acids. Six amino acids were examined - L-cysteine ethyl ester hydrochloride, alanine, gamma-aminobutyric acid, L-histidine, L-proline and sodium glutamate - as CO release promoters. Among the examined promoters, sodium glutamate shows the highest efficiency in promoting CO release from complex 1. The overall CO release involves multiple steps with different mechanisms, with an initially slow CO releasing process followed by a much faster one. The duration of the slow process is solvent-dependant. In D2O and physiological saline (in D2O), this slow process lasted much longer compared to that in DMSO. Cytotoxic assessments of the systems containing glutamate and L-cysteine ethyl ester hydrochloride suggest that the examined amino acid and amino acid derivative showed stronger cytotoxicities than cysteamine.