Multi-omics approaches to disease.
Multi-omics approaches to disease.
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DOI：
10.1186/s13059-017-1215-1
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发表时间：
2017-05-05
期刊：
影响因子：
12.3
通讯作者：
Lusis A
中科院分区：
文献类型：
--
作者：
Hasin Y;Seldin M;Lusis A
高通量技术使医学研究发生了革命性的变化。基因分型阵列的出现使得大规模全基因组关联研究和检测全球转录物水平的方法成为可能，从而产生了“整合遗传学”领域。其他组学技术，如蛋白质组学和代谢组学，现在经常被纳入生物学研究人员的日常方法中。在这篇综述中，我们提供了这类组学技术的概述，并重点介绍了跨多个组学层集成这些技术的方法。与单一组学类型的研究相比，多组学提供了了解疾病背后信息流的机会。
High-throughput technologies have revolutionized medical research. The advent of genotyping arrays enabled large-scale genome-wide association studies and methods for examining global transcript levels, which gave rise to the field of “integrative genetics”. Other omics technologies, such as proteomics and metabolomics, are now often incorporated into the everyday methodology of biological researchers. In this review, we provide an overview of such omics technologies and focus on methods for their integration across multiple omics layers. As compared to studies of a single omics type, multi-omics offers the opportunity to understand the flow of information that underlies disease.