A NOVEL PROCESS FOR THE MANUFACTURING OF POROUS GRAFTS - PROCESS DESCRIPTION AND PRODUCT EVALUATION
A NOVEL PROCESS FOR THE MANUFACTURING OF POROUS GRAFTS - PROCESS DESCRIPTION AND PRODUCT EVALUATION
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DOI：
10.1002/jbm.820170203
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发表时间：
1983-01-01
期刊：
影响因子：
--
通讯作者：
WILSON, GJ
中科院分区：
文献类型：
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作者：
LEIDNER, J;WONG, EWC;WILSON, GJ
开发了一种由聚合物溶液或熔体制造多孔血管移植物的新工艺。它允许制造具有可控孔隙率、孔径和机械性能的移植物。在该过程中，聚合物熔体或聚合物溶液通过细孔挤出;然后纤维被拉伸并缠绕在旋转的心轴上。发生纤维-纤维粘合，从而形成稳定的多孔管。已研究了工艺变量对所得移植物物理性能的影响，犬体内试验评价证明了小（4 mm）和大（10 mm）口径配置下的移植物通畅性，新生内膜薄且稳定。
A novel process has been developed for the manufacture of porous vascular grafts from solutions or melts of polymers. It allows the manufacture of grafts with controllable porosity, pore size, and mechanical properties. In this process, the polymer melt or polymer solution is extruded through fine orifices; the fibers are then fibers are then stretched and wound on a rotating mandril. Fiber‐fiber bonding takes place, resulting in the formation of stable porous tubes. The effects of the process variables on the physical properties of the resulting graft have been studied and preliminaryin vivoevaluation in dogs has demonstrated graft patency with a thin, stable neointima in both small (4 mm) and large (10 mm) caliber configurations.