Separate the Sheep from the Goats: Use and Limitations of Large Animal Models in Intervertebral Disc Research.
Separate the Sheep from the Goats: Use and Limitations of Large Animal Models in Intervertebral Disc Research.
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DOI：
10.2106/jbjs.17.00172
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发表时间：
2017-10
期刊：
影响因子：
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通讯作者：
Sandra Reitmaier;F. Graichen;A. Shirazi-Adl;H. Schmidt
中科院分区：
文献类型：
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作者：
Sandra Reitmaier;F. Graichen;A. Shirazi-Adl;H. Schmidt
在1985年至2016年发表的已确定研究中，约有5，168只大型动物（猪，绵羊，山羊和牛）用于椎间盘研究。大多数审查的研究显示，科学影响力低，动物模型缺乏合理的理由，以及动物实验文件中的一些缺陷。动物模型在椎间盘研究中具有转化价值的假设，科学界应采取适当的措施进行调查。为今后的调查提供了建议，以提高椎间盘研究的动物研究的质量，有效性和实用性。需要进行更多的体内研究，以全面评估动物模型在各种应用中的适用性，并帮助将动物模型作为椎间盘研究的一个不可分割的补充部分。
Approximately 5,168 large animals (pigs, sheep, goats, and cattle) were used for intervertebral disc research in identified studies published between 1985 and 2016. Most of the reviewed studies revealed a low scientific impact, a lack of sound justifications for the animal models, and a number of deficiencies in the documentation of the animal experimentation. The scientific community should take suitable measures to investigate the presumption that animal models have translational value in intervertebral disc research. Recommendations for future investigations are provided to improve the quality, validity, and usefulness of animal studies for intervertebral disc research. More in vivo studies are warranted to comprehensively evaluate the suitability of animal models in various applications and help place animal models as an integral, complementary part of intervertebral disc research.