Ocular Surface Ion-Channels Are Closely Related to Dry Eye: Key Research Focus on Innovative Drugs for Dry Eye.
Ocular Surface Ion-Channels Are Closely Related to Dry Eye: Key Research Focus on Innovative Drugs for Dry Eye.
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眼表离子通道与干眼密切相关：干眼创新药物研究重点
DOI：
10.3389/fmed.2022.830853
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发表时间：
2022
影响因子：
3.9
通讯作者：
Jin X
中科院分区：
文献类型：
--
作者：
Yang S;Wu Y;Wang C;Jin X
眼表存在丰富的离子通道，包括各种感知受体、氯离子通道、嘌呤能受体通道和水通道，在干眼症的发病机制中起重要作用。靶向干眼病的激活剂或抑制剂化合物在体内和体外实验中显示出积极的作用，已成为干眼病药物研发的重点，个别化合物已应用于临床实验治疗。本文综述了与干眼症相关的眼表离子通道的类型、基本功能和空间分布，并讨论了各种离子通道受体调节化合物的基础和临床研究成果。因此，进一步阐明离子通道与干眼症的关系，将为干眼症靶向药物治疗的研究提供理论依据。
Abundant ion-channels, including various perceptual receptors, chloride channels, purinergic receptor channels, and water channels that exist on the ocular surface, play an important role in the pathogenesis of dry eye. Channel-targeting activators or inhibitor compounds, which have shown positive effects in in vivo and in vitro experiments, have become the focus of the dry eye drug research and development, and individual compounds have been applied in clinical experimental treatment. This review summarized various types of ion-channels on the ocular surface related to dry eye, their basic functions, and spatial distribution, and discussed basic and clinical research results of various channel receptor regulatory compounds. Therefore, further elucidating the relationship between ion-channels and dry eye will warrant research of dry eye targeted drug therapy.
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影响因子：
5.3
作者：
Fernandez-Trillo, Jorge;Florez-Paz, Danny;Gomis, Ana
通讯作者：
Gomis, Ana
影响因子：
5.6
作者：
Burnstock G
通讯作者：
Burnstock G
影响因子：
5.6
作者：
Fakih D;Baudouin C;Réaux-Le Goazigo A;Mélik Parsadaniantz S
通讯作者：
Mélik Parsadaniantz S
影响因子：
9.3
作者：
Fakih D;Guerrero-Moreno A;Baudouin C;Réaux-Le Goazigo A;Parsadaniantz SM
通讯作者：
Parsadaniantz SM
影响因子：
--
作者：
Baiula M;Spampinato S
通讯作者：
Spampinato S