Brief Report: Apparent Antiretroviral Overadherence by Pill Count is Associated With HIV Treatment Failure in Adolescents.
Brief Report: Apparent Antiretroviral Overadherence by Pill Count is Associated With HIV Treatment Failure in Adolescents.
复制标题
DOI：
10.1097/qai.0000000000000994
复制
发表时间：
2016-08-15
期刊：
影响因子：
--
通讯作者：
Lowenthal, Elizabeth
中科院分区：
文献类型：
--
作者：
Okatch, Harriet;Beiter, Kaylin;Lowenthal, Elizabeth
在许多情况下，使用计算出的依从性百分比的药丸计数来监测依从性，但可能会被患者丢弃药丸以隐藏不依从性所破坏。药丸计数表明服用了>100%的处方剂量可能表明“药丸倾倒”。“我们将300名HIV感染青少年的队列中的“过度依从性”定义为在一年的随访期间，超过三分之一的药丸数量超过100%。明显的过度依从性在病毒学失败的患者中比在病毒载量抑制的患者中更常见（33%vs13%，chi（2）P = 0.001）。反复服药次数>100%可能会导致HIV感染青少年治疗失败的风险增加。
Pill counts with calculated adherence percentages are used in many settings to monitor adherence, but can be undermined by patients discarding pills to hide nonadherence. Pill counts suggesting that >100% of prescribed doses were taken can signal "pill dumping." We defined "overadherence" among a cohort of 300 HIV-infected adolescents as having greater than one-third of pill counts with >100% adherence during a year of follow-up. Apparent overadherence was more common in those with virologic failure than in those with suppressed viral loads (33% vs 13%, chi(2) P = 0.001). Pill count adherence repeatedly >100% may identify HIV-infected adolescents at increased risk of treatment failure.