IMPLANTATION OF BACTEROIDES-GINGIVALIS IN NONHUMAN-PRIMATES INITIATES PROGRESSION OF PERIODONTITIS
IMPLANTATION OF BACTEROIDES-GINGIVALIS IN NONHUMAN-PRIMATES INITIATES PROGRESSION OF PERIODONTITIS
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DOI：
10.1126/science.3336774
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发表时间：
1988-01-01
期刊：
影响因子：
56.9
通讯作者：
KORNMAN, KS
中科院分区：
文献类型：
--
作者：
HOLT, SC;EBERSOLE, J;KORNMAN, KS
虽然牙周炎是一种细菌性疾病，但其多面性和细菌的复杂性使得很难确切地证明特定的微生物启动了疾病的过程。成功地将牙周病原体牙龈类杆菌利福平耐药株植入猕猴牙周微生物群中，导致全身对该微生物抗体水平的提高和迅速而显著的骨丢失。
Although periodontitis is a bacterial disease, its multidimensional nature and its bacterial complexity have made it difficult to definitively prove that specific microorganisms initiate the disease process. The successful implantation of a rifampin-resistant strain of the putative periodonatal pathogen Bacteroides gingivalis into the periodontal microbiota of monkeys (Macaca fasicularis) resulted in an increase in the systemic levels of antibody to the microorganism and rapid and significant bone loss.